研究業績

濱田文彦  千葉政一 三浦真弘　
　　

濱田文彦

  1. Yamamiya K, Li X, Nabeka H, Khan S, Khan F, Wakisaka H, Saito S, Hamada F, Matsuda S: Tracking of Prosaposin, a Saposin
    Precursor, in Rat Testis. J Histochem Cytochem. 71(10):537-554, 2023.
  2. Khan S, Takeuchi A, Nabeka H, Khan F, Shimokawa T, Takanezawa S, Saitou T, Imamura T, Tachibana T, Nishizono A, Hamada F,
    Matsuda S: Administration of prosaposin-derived neurotrophic factor toneural tube defects facilitatesregeneration and restoresneurological functions. iScience 26, 2023.
  3. Dong X, Chiba S,Shimada T, Hamada F: A Statistical Evaluation of Uncoupling Protein 1 in the Limited Area of Brown Adipose Tissue by Immunoelectron Microscopy. Computational Chemistry 10, 121-137, 2022.
  4. Kawashima T, Ji RC, Itoh Y, Agata N, Sasai N, Murakami T, Sokabe M, Hamada F, Kawakami K: Morphological and biochemical changes of lymphatic vessels in the soleus muscle of mice after hindlimb unloading. Muscle Nerve 64(5), 620-628, 2021.
  5. Abe M, Miura M, Hamada F, Sugio K. : Arterial blood supply patterning of the mammary sentinel lymph nodes with special reference to the relation of the formation mechanism of the superficial subscapular artery. Anat Sci Int 96, 489-508, 2021.
  6. Taniguchi M, Nabeka H, Yamamiya K, Khan MSI, Shimokawa T, Islam F, Doihara T, Wakisaka H, Kobayashi N, Hamada F, Matsuda S.: The expression of prosaposin and its receptors, GRP37 and GPR37L1, are increased in the developing dorsal root ganglion. PLoS One 16, e0255958, 2021.
  7. Ninomiya R, Kubo S, Baba T, Kajiwara T, Tokunaga A, Nabeka H, Doihara T, Shimokawa T, Matsuda S, Murakami K, Aigaki T, Yamaoka Y, Hamada F: Inhibition of low-density lipoprotein uptake by Helicobacter pylori virulence factor CagA. Biochem. Biophys. Res.Commun. 556, 192-198, 2021.
  8. Kunihiro J, Nabeka H, Wakisaka H, Unuma K, Khan MSI, Shimokawa T, Islam F, Doihara T, Yamamiya K, Saito S, Hamada F, Matsuda S.:Prosaposin and its receptors GRP37 and GPR37L1 show increased immunoreactivity in the facial nucleus following facial nerve transection.PLoS One. 15(12), e0241315, 2020.
  9. Iwasaki K, Ninomiya R, Shin T, Nomura T, Kajiwara T, Hijiya N, Moriyama M, MimataH, Hamada F.: Chronic hypoxia-induced slug promotes invasive behavior of prostate cancer cells by activating expression of ephrin-B1. Cancer Sci. 109 (10), 3159-3170, 2018.
  10. Nabeka H, Saito S, Li X, Shimokawa T, Md. Sakirul Islam Khan, Yamamiya K, Kawabe S, Doihara T, Hamada F, Kobayashi N, Matsuda S.: Interneurons secrete prosaposin, a neurotrophic factor, to attenuate kainic acid-induced neurotoxicity.IBRO Reports 3, 17-32, 2017.
  11. Khan MSI, Nabeka H, IslamF, Shimokawa T, Saito S, LiX, Kawabe S, Hamada F, Tachibana T, Matsuda S.: Early neonatal loss of inhibitorysynaptic input to the spinal motor neurons confers spina bifida-like leg dysfunction in a chicken model. Dis Model Mech. 10(12), 421-1432, 2017.
  12. Nabeka H, Shimokawa T, Doihara T, Saito S, Wakisaka H, Hamada F, Kobayashi N, Matsuda S.: A prosaposin-derived Peptide alleviates kainic Acid-induced brain injury. PLoS One. 10(5), e0126856,2015.
  13. Li C, Gao, HL, Shimokawa T, Nabeka H, Hamada F, Araki H, Cao YM, Kobayashi N, Matsuda S: Prosaposin expression in the regenerated muscles of mdx and cardiotoxin-treated mice. Histol. Histopathol. 28 (7), 875-892, 2013.
  14. Taniue K, Nishida A, Hamada F, Sugie A, Oda T, Ui-Tei K, Tabata T, Akiyama T: Sunspot, a link between Wingless signaling and endoreplication in Drosophila. Development 137, 1755-1764, 2010.
  15. Miguchi Y, Takata H, Doihara T, Miyawaki K, Shimokawa T, Hamada F, Kobayashi N, Matsuda S: Morphological maturation level of the esophagus is associated with the number of circumesophageal muscle fibers during archenteron formation in the starfish Patiria (Asterina) pectinifera. Biol. Bul. l219, 12-6, 2010.
  16. Matsuda S, Hamada F, Ishizuka N: The Structure of Dendritic Spines in Dendritic Spines: Biochemistry, Modeling and Properties, pp151-162, NOVA Science publisher(2009)
  17. Doihara T, Miguchi, Y, Miyawaki K, Shimokawa T, Hamada F, Kobayashi N, Matsuda S: Spatiotemporal distribution patterns of oligosaccharides during early embryogenesis in the starfish Patiria pectinifera. Dev. Genes. Evol. 219, 199-206, 2009.
  18. Tran, H, Hamada F, Schwarz-Romond T, Bienz M: Trabid, a new positive regulator of Wnt-induced transcription with preference for binding to and cleaving K63-linked ubiquitin chains. Genes Dev 22, 528-542, 2008.
  19. Hosoda Y, Miyawaki K, Saito S, Chen J, Bing X, Terashita T, Kobayashi N, Araki N, Shimokawa T, Hamada F, Sano A, Tanabe H, Matsuda S: Distribution of prosaposin in the rat nervous system. Cell Tissue Res. 330, 197-207, 2007.
  20. Hamada F & Bienz M: The APC tumor suppressor binds to C-terminal binding protein to divert nuclear b-catenin from TCF. Dev. Cell 7, 677-685, 2004.
  21. Bienz M. & Hamada F: Adenomatous polyposis coli proteins and cell adhesion. Curr. Opin. Cell Biol. 16, 528-535, 2004.
  22. Cliffe A, Hamada F, Bienz M: A role of Dishevelled in relocating Axin to the plasma membrane during Wingless signaling. Curr. Biol. 13, 960-966, 2003.
  23. Hamada F. & Bienz M: A Drosophila APC tumour suppressor homolog functions in cellular adhesion. Nat. Cell Biol. 4, 208-213, 2002.
  24. Haraguchi K, Satoh K, Yanai H, Hamada F, Kawabuchi M, Akiyama T: The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase. Genes Cells. 5, 905-912, 2000.
  25. Kawahara K, Morishita T, Nakamura T, Hamada F, Toyoshima K, Akiyama T: Down-regulation of b-catenin by the colorectal tumor suppressor APC requires association with Axin and b-catenin. J. Biol. Chem. 275, 8369-8374, 2000.
  26. Hamada F, Murata Y, Nishida A, Fujita F, Tomoyasu Y, Nakamura M, Toyoshima K, Tabata T, Ueno N, Akiyama T: Identification and characterization of E-APC, a novel Drosophila homologue of the tumor suppressor APC. Genes Cells. 4, 465-474, 1999.
  27. Hamada F, Tomoyasu Y, Takatsu Y, Nakamura M, Nagai S, Suzuki A, Fujita F, Shibuya H, Toyoshima K, Ueno N, Akiyama T: Negative regulation of Wingless signaling by D-Axin, a Drosophila homolog of Axin. Science 283, 1739 - 1742, 1999.
  28. Nakamura T, Hamada F, Ishidate T, Anai K, Kawahara K, Toyoshima K, Akiyama T: Axin, an inhibitor of the Wnt signalling pathway, interacts with -catenin, GSK-3 b and APC and reduces the b -catenin level. Genes Cells 3, 395-403, 1998.
  29. Bhattacharjee, R. N, Hamada F, Toyoshima K, Akiyama T: The tumor suppressor gene product APC is hyperphosphorylated during the M phase. Biochem. Biophys. Res. Commun. 220, 192-195, 1996.
  30. Hitsumoto Y, Song D. S, Okada M, Hamada F, Saheki S, Takeuchi N: Enhancement of CD3-mediated thymocyte apoptosis by the cross-linkage of heat-stable antigen. Immunology 89, 200-204, 1996.
  31. Hamada F, Aoki M, Akiyama T, Toyoshima K: Association of immunoglobulin G Fc receptor II with Src-like protein tyrosine kinase Fgr in neutrophils. Proc. Natl. Acad. Sci. USA 90, 6305-6309, 1993.
  32. Aoki M, Hamada F, Sugimoto T, Sumida S, Akiyama T, Toyoshima K: The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation. J. Biol. Chem. 268, 22723-22732, 1993.
  33. Hitsumoto Y, Ohnishi H, Nakano A, Hamada F, Saheki S, Takeuchi N: Inhibition of homologous complement activation by the heat-stable antigen. Int. Immunol. 5, 805-808, 1993.
  34. Hitsumoto Y, Nakano A, Ohnishi H, Hamada F, Saheki S, Takeuchi N: Purification of the murine heat-stable antigen from erythrocytes. Biochem. Biophys. Res. Commun. 187, 773-777, 1992.



千葉政一　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　日常診療に役立つ医学情報

  1. Dong X, Chiba S, Shimada T, Hamada F: A Statistical Evaluation of Uncoupling Protein 1 in the Limited Area of Brown Adipose Tissue by Immunoelectron Microscopy. Computational Chemistry 10, 121-137, 2022.
  2. 酒井久美子、千葉政一、西内美香、駒井三千夫: 亜鉛を軸にした新しい代謝経路の解析方法. Medical Science Digest
    47巻3月号(通巻618号)2021.
  3. Yan Q, Ina K, Chiba S, Wei H, Tatsukawa S,Fujikura Y.: The signal pathway for the repressive effect of dipyridamole on myofibroblast transdifferentiation. J Cell Mole Med. 23(2),1608-1612, 2019.
  4. Ando H, Gotoh K, Fujiwara K, Anai M, Chiba S, Masaki T, Kakuma T, Shibata H: Glucagon-like peptide-1 reduces pancreatic beta-cell mass through hypothalamic neural pathways in high-fat diet-induced obese rats. Sci Rep 7:5578, 2017.
  5. 千葉政一：基礎医学研究の今。肥満研究　68(2):130-131, 2017.
  6. 千葉政一、森脇千夏、伊奈啓輔、藤倉義久：摂食と肥満における視床下部神経ヒスタミンの役割:創薬へ向けて。日本薬理学会雑誌 147:1-8, 2016 .
  7. 大隈まり、千葉政一 、中原 成浩：脳神経外科治療と食行動異常を伴う代謝性疾患群 (それぞれの診療科における肥満症の問題点) . 日本肥満学会誌 21(3), 149-154, 2015 .
  8. Ando H, Gotoh K, Fujiwara K, Anai M, Chiba S, Masaki T, Kakuma T, Shibata H: Glucagon-like peptide-1 reduces pancreatic beta-cell mass through hypothalamic neural pathways in high-fat diet-induced obese rats. Sci Rep 7:5578, 2017.
  9. 佐藤文憲、安藤忠助、澁谷忠正、佐藤竜太、秦 聡孝、森 健一、野村威雄、三股浩光、正木孝幸、後藤孔郎、千葉政一、柴田洋孝:当科における生体腎移植ドナーのbody mass indexと周術期成績に関する検討 (シンポジウム 腎移植,更なる成績の向上のために．技術の進歩と応用によるハイリスク症例への対応) 。西日本泌尿器科 (The Nishinihon journal of urology）78(6):277-283, 2016.
  10. Aosa T, Chiba S, Kitamura H, Ina K, Tatsukawa S, Moriwaki C, Wei H, Gotoh K, Masaki T, Kakuma T, Shibata H, Fujikura Y: Pore alterations of the endothelial lining of rat fenestrated intestinal capillaries exposed to acute stress. Histol. Histopathol. 31(7):807-817, 2016.
  11. Moriwaki C, Chiba S, Wei H, Aosa T, Kitamura H, Ina K, Shibata H, Fujikura Y: Distribution of histaminergic neuronal cluster in the rat and mouse hypothalamus.J Chem Neuroanat 68:1-13, 2015.
  12. Wei H, Chiba S, Moriwaki C, Kitamura H, Ina K, Aosa T, Tomonari K, Gotoh K, Masaki T, Katsuragi I, Noguchi H, Kakuma T, Hamaguchi K, Shimada T, Fujikura Y, Shibata H: A clinical approach to brown adipose tissue in the para-aortic area of the human thorax. PloS one 10:e0122594, 2015.
  13. Mitsutomi K, Masaki T, Shimasaki T, Gotoh K, Chiba S, Kakuma T, Shibata H: Effects of a nonnutritive sweetener on body adiposity and energy metabolism in mice with diet-induced obesity. Metabolism 63:69-78, 2014
  14. Kakuma T, Chiba S, Takahashi Y, Kai K, Tsubone T. Yoshimatsu H: Self-weighing contributes to glycemic control: importance of measuring body weight. Diabetol Int  4, 40-44, 2013
  15. Gotoh K, Inoue M, Masaki T, Chiba S, Shiraishi K, Shimasaki T, Matsuoka K, Ando H, Fujiwara K, Fukunaga N, Aoki K, Nawata T, Katsuragi I, Kakuma T, Seike M, Yoshimatsu HGotoh K, Inoue M, Masaki T, Chiba S, Shiraishi K, Shimasaki T, Matsuoka K, Ando H, Fujiwara K, Fukunaga N, Aoki K, Nawata T, Katsuragi I, Kakuma T, Seike M, Yoshimatsu H: Obesity-related chronic kidney disease is associated with spleen-derived IL-10. Nephrol Dial Transplant 28:1120-1130, 2013.
  16. Gotoh K, Masaki T, Chiba S, Ando H, Fujiwara K, Shimasaki T, Mitsutomi K, Katsuragi I, Kakuma T, Sakata T, Yoshimatsu H: Hypothalamic brain-derived neurotrophic factor regulates glucagon secretion mediated by pancreatic efferent nerves. J Neuroendocrinol 25:302-311, 2013.
  17. Gotoh K, Masaki T, Chiba S, Ando H, Fujiwara K, Shimasaki T, Mitsutomi K, Katsuragi I, Kakuma T, Sakata T, Yoshimatsu H: Brain-derived neurotrophic factor, corticotropin-releasing factor, and hypothalamic neuronal histamine interact to regulate feeding behavior.  J Neurochem 125:588-598, 2013.
  18. Gotoh K, Masaki T, Chiba S, Ando H,Shimasaki T, Mitsutomi K, Fujiwara K, Katsuragi I, Kakuma T, Sakata T, Yoshimatsu H: Nesfatin-1, corticotropin-releasing hormone, thyrotropin-releasing hormone, and neuronal histamine interact in the hypothalamus to regulate feeding behavior.  J　Neurochem 124:90-99, 2013.
  19. Shimasaki T, Masaki T, Mitsutomi K, Ueno D, Gotoh K, Chiba S, Kakuma T, Yoshimatsu H: The dipeptidyl peptidase-4 inhibitor des-fluoro-sitagliptin regulates brown adipose tissue uncoupling protein levels in mice with diet-induced obesity.  PloS one 8:e63626, 2013.
  20. Ueno D, Masaki T, Gotoh K, Chiba S, KakumaT, Yoshimatsu H: Cilnidipine regulates glucose metabolism and levels of high-molecular adiponectin in diet-induced obese mice.  Hypertens Res 36:196-201, 2013.


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