研究業績

2026

Investigation in the selective targeting of homologous recombination-deficient cells by benzophenanthridine alkaloid nitidine.

Yoshihiro Nishida, Takeshi Terabayashi, Sawako Adachi, Tomoko Okuma, Toshimasa Ishizaki, Tadashi Tomo, Katsuhiro Hanada Scientific reports 1-15 2026年7月8日

DOI: https://doi.org/10.1038/s41598-026-61663-8

Mitotic abnormality induced by evodiamine, a tryptamine indole alkaloid

Ryoya Shigefuji, Seiji Komatsu, Takeshi Terabayashi, Toshimasa Ishizaki, Tadashi Tomo, Yoshihiro Nishida, Katsuhiro Hanada Toxicology and Applied Pharmacology 117813-117813 2026年6月

DOI: https://doi.org/10.1016/j.taap.2026.117813

RPE With ROCK-Mediated Epithelial-Mesenchymal Transition as a Key Contributor of Subretinal Fibrosis in AMD

Iori Wada, Keijiro Ishikawa, Muneo Yamaguchi, Shotaro Shimokawa, Ji Rui, Kenichiro Mori, Yoshihiro Kaizu, Mitsuru Arima, Shoji Notomi, Yusuke Murakami, Shigenori Inagaki, Yuta Kohro, Makoto Tsuda, Kensuke Shibata, Ryo Terao, Takeshi Terabayashi, Toshimasa Ishizaki, Shigeo Yoshida, Tatsuro Ishibashi, Susumu Ishida, Rajendra S Apte, Koh-Hei Sonoda, Shintaro Nakao

Investigative Ophthalmology & Visual Science 67(5) 33-33 2026年5月14日

DOI: https://doi.org/10.1167/iovs.67.5.33

Loss of ErbB3 redirects Integrin β1 from early endosomal recycling to secretion in extracellular vesicles

Dorival Mendes Rodrigues-Junior, Ana Rosa Sáez-Ibáñez, Takeshi Terabayashi, Nina Daubel, Taija Mäkinen, Olof Idevall-Hagren, Aristidis Moustakas, Ingvar Ferby

Journal of Cell Biology 225(1) 2026年1月5日

DOI: https://doi.org/10.1083/jcb.202501255

2025

Fibulin-4 is required for the mechanical stability of tendons

Takako Sasaki, Kyoko Jin, Aki Takimoto, Yuki Taga, Yoshihiro Ishikawa, Hans Peter Bächinger, Takao Sakai, Takeshi Terabayashi, Katsuhiro Hanada, Ursula Schlötzer-Schrehardt, Chisa Shukunami, Yuji Hiraki, Tomoyuki Nakamura, Ei Yamamoto

Cell and Tissue Research 402(3) 361-372 2025年11月13日

DOI: https://doi.org/10.1007/s00441-025-04028-3

Helicobacter pylori base-excision restriction enzyme in stomach carcinogenesis.

Masaki Fukuyo, Noriko Takahashi, Katsuhiro Hanada, Ken Ishikawa, Česlovas Venclovas, Koji Yahara, Hideo Yonezawa, Takeshi Terabayashi, Yukako Katsura, Naoki Osada, Atsushi Kaneda, M Constanza Camargo, Charles S Rabkin, Ikuo Uchiyama, Takako Osaki, Ichizo Kobayashi

PNAS nexus 4(8) pgaf244 2025年8月5日

DOI: https://doi.org/10.1093/pnasnex us/pgaf244

Big data-driven target identification by machine learning: DRD2 as a therapeutic target for psoriasis.

Takashi Sakai, Ryusuke Sawada, Otoha Ichinose, Takeshi Terabayashi, Yutaka Hatano, Yoshihiro Yamanishi, Toshimasa Ishizaki

Journal of dermatological science 119(1) 9-17 2025年7月

DOI: https://doi.org/10.1016/j.jdermsci.2025.04.012

Analysis of accumulation of DNA double-strand breaks in mouse tissues by pulsed-field gel electrophoresis

Takeshi Terabayashi, Takako Sasaki, Toshimasa Ishizaki, Tadashi Tomo, Yoshihiro Nishida, Katsuhiro Hanada

Toxicology and Applied Pharmacology 497 117278-117278 2025年4月

DOI: https://doi.org/10.1016/j.taap.2025.117278

2024

Timosaponin AIII Disrupts Cell–Extracellular Matrix Interactions through the Inhibition of Endocytic Pathways

Takeshi Terabayashi, Daisuke Takezaki, Katsuhiro Hanada, Shigeru Matsuoka, Takako Sasaki, Takahiro Akamine, Akira Katoh, Toshimasa Ishizaki

Biological and Pharmaceutical Bulletin 47(10) 1648-1656 2024年10月11日

DOI: https://doi.org/10.1248/bpb.b24-00403

Conditional deficiency of Rho-associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice

Takahiro Akamine, Takeshi Terabayashi, Takako Sasaki, Riku Hayashi, Ichitaro Abe, Fumihiro Hirayama, Shinichi Nureki, Masahito Ikawa, Haruhiko Miyata, Akinori Tokunaga, Takashi Kobayashi, Katsuhiro Hanada, Dean Thumkeo, Shuh Narumiya, Toshimasa Ishizaki

FEBS open bio 14(6) 906-921 2024年6月

DOI: https://doi.org/10.1002/2211-5463.13802

Caspase-4 has a role in cell division in epithelial cells through actin depolymerization

Kazuhiro Sumida, Tomomitsu Doi, Kunie Obayashi, Yosuke Chiba, Shohei Nagasaka, Noriyoshi Ogino, Koichiro Miyagawa, Ryoko Baba, Hiroyuki Morimoto, Hideki Hara, Takeshi Terabayashi, Toshimasa Ishizaki, Masaru Harada, Motoyoshi Endo

Biochemical and Biophysical Research Communications 695 149394-149394

2024年2月5日

DOI: https://doi.org/10.1016/j.bbrc.2023.149394

2022

Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition

Masahiro Nishida, Takeshi Terabayashi, Shigeru Matsuoka, Tomoko Okuma, Sawako Adachi, Tadashi Tomo, Masanori Kawano, Kazuhiro Tanaka, Hiroshi Tsumura, Hirofumi Anai, Toshimasa Ishizaki, Yoshihiro Nishida, Katsuhiro Hanada

Communications Biology 5(1) 982-982 2022年9月16日

DOI: https://doi.org/10.1038/s42003-022-03920-w

A novel mRNA decay inhibitor abolishes pathophysiological cellular transition.

Daisuke Kami, Toshimasa Ishizaki, Toshihiko Taya, Akira Katoh, Hiroyuki Kouji, Satoshi Gojo

Cell death discovery 8(1) 278-278 2022年6月7日

DOI: https://doi.org/10.1038/s41420-022-01076-4

Potential mechanism of hepatic lipid accumulation during a long-term rest phase restricted feeding in mice.

Yuya Tsurudome, Takahiro Akamine, Michiko Horiguchi, Yukiyo Wada, Akio Fujimura, Kentaro Ushijima

Chronobiology international 39(8) 1132-1143 2022年5月23日

DOI: https://doi.org/10.1080/07420528.2022.2077746

Involvement of activator protein-1 family members in β-catenin and p300 association on the genome of PANC-1 cells.

Tomomitsu Doi, Hironori Hojo, Shinsuke Ohba, Kunie Obayashi, Motoyoshi Endo, Toshimasa Ishizaki, Akira Katoh, Hiroyuki Kouji

Heliyon 8(2) e08890 2022年2月

DOI: https://doi.org/10.1016/j.heliyon.2022.e08890

2021

Increased unfolded protein responses caused by MED17 mutations

Takeshi Terabayashi, Satoru Hashimoto

Neurogenetics 2021年8月15日

DOI: https://doi.org/10.1007/s10048-021-00661-6

The benzylisoquinoline alkaloids, berberine and coptisine, act against camptothecin-resistant topoisomerase I mutants.

Naomi Inoue, Takeshi Terabayashi, Yuri Takiguchi-Kawashima, Daisuke Fujinami, Shigeru Matsuoka, Masanori Kawano, Kazuhiro Tanaka, Hiroshi Tsumura, Toshimasa Ishizaki, Hisashi Narahara, Daisuke Kohda, Yoshihiro Nishida, Katsuhiro Hanada

Scientific reports 11(1) 7718-7718 2021年4月8日

DOI: https://doi.org/10.1038/s41598-021-87344-2

Timosaponin Aiii Disrupts Morphological Plasticity and Migration of Breast Adenocarcinoma Through Inhibition of Integrin Internalisation

Takeshi Terabayashi, Katsuhiro Hanada, Shigeru Matsuoka, Takako Sasaki, Akira Katoh, Takahiro Akamine, Toshimasa Ishizaki

Reserch Square 2021年3月15日

DOI: https://doi.org/10.21203/rs.3.rs-276535/v1

2020

Disruption of Actin Dynamics Regulated by Rho Effector mDia1 Attenuates Pressure Overload-Induced Cardiac Hypertrophic Responses and Exacerbates Dysfunction.

Ichitaro Abe, Takeshi Terabayashi, Katsuhiro Hanada, Hidekazu Kondo, Yasushi Teshima, Yumi Ishii, Miho Miyoshi, Shintaro Kira, Shotaro Saito, Hirotsugu Tsuchimochi, Mikiyasu Shirai, Kunio Yufu, Motoki Arakane, Tsutomu Daa, Dean Thumkeo, Shuh Narumiya, Naohiko Takahashi, Toshimasa Ishizaki

Cardiovascular research 117(4) 1103-1117 2020年7月9日

DOI: https://doi.org/10.1093/cvr/cvaa206

Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches.

Naoki Kusunose, Akito Tsuruta, Kengo Hamamura, Yuya Tsurudome, Yuya Yoshida, Takahiro Akamine, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo

Genes to cells : devoted to molecular & cellular mechanisms 25(4) 270-278 2020年4月

DOI: https://doi.org/10.1111/gtc.12758

mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse.

D Thumkeo, Y Katsura, Y Nishimura, P Kanchanawong, K Tohyama, T Ishizaki, S Kitajima, C Takahashi, T Hirata, N Watanabe, M F Krummel, S Narumiya

Science advances 6(1) eaay2432 2020年1月

DOI: https://doi.org/10.1126/sciadv.aay2432

Analysis of Chromosomal DNA Fragmentation in Apoptosis by Pulsed-Field Gel Electrophoresis.

Takeshi Terabayashi, Asako Tokumaru, Toshimasa Ishizaki, Katsuhiro Hanada

Methods in molecular biology (Clifton, N.J.) 2119 89-99 2020年

DOI: https://doi.org/10.1007/978-1-0716-0323-9_8


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