近年、臨床のためのエビデンスを生み出し、患者さまに還元するには多施設共同研究がかかせません。
当講座は特定非営利活動法人 婦人科悪性腫瘍研究機構(ＪＧＯＧ)の認定施設として、数多くの多施設共同研究に参加しています。
また、インターグループとしては、関西臨床研究会(ＫＣＯＧ)に属し、多施設共同研究への参加および自施設から研究責任者を立て、新たな臨床研究を実行しています。
主な発表論文
1. Matsumoto H, Nasu K, Shikama A, Shiozaki T, Futagami M, Kai K, Mori T, Yano M, Yamada T, Teramoto N. Pathological processes and pretreatment cytologic diagnosis of neuroendocrine carcinoma of the endometrium: addendum report of the Kansai Clinical Oncology Group/Intergroup study in Japan. Med Mol Morphol. 2021 May 2. doi: 10.1007/s00795-021-00288-4. Epub ahead of print. PMID: 33934220.
2. Kai K, Nasu K, Nishida H, Daa T, Shikama A, Shiozaki T, Kurakazu M, Yano M, Imamura Y, Tokunaga H, Tasaki K, Iida Y, Yamada Y, Morisawa H, Nakagawa S, Fujimoto E, Tsuruta T, Matsumoto H, Arakawa A, Nonaka M, Takano H, Ushiwaka T, Mori T, Ito K, Motohashi T, Teramoto N, Yamada T. Correlation of World Health Organization 2010 Classification for Gastroenteropancreatic Neuroendocrine Neoplasms with the Prognosis of Ovarian Neuroendocrine Neoplasms: Kansai Clinical Oncology Group-Protocol Review Committee/Intergroup Study. Neuroendocrinology. 2021;111(4):320-329. doi: 10.1159/000506743. Epub 2020 Feb 25. PMID: 32097950.
3. Matsumoto H, Shimokawa M, Nasu K, Shikama A, Shiozaki T, Futagami M, Kai K, Nagano H, Mori T, Yano M, Sugino N, Fujimoto E, Yoshioka N, Nakagawa S, Shimada M, Tokunaga H, Yamada Y, Tsuruta T, Tasaki K, Nishikawa R, Kuji S, Motohashi T, Ito K, Yamada T, Teramoto N. Clinicopathologic features, treatment, prognosis and prognostic factors of neuroendocrine carcinoma of the endometrium: a retrospective analysis of 42 cases from the Kansai Clinical Oncology Group/Intergroup study in Japan. J Gynecol Oncol. 2019 Nov;30(6):e103. doi: 10.3802/jgo.2019.30.e103. PMID: 31576694; PMCID: PMC6779616.
4. Hirakawa T, Minaguchi T, Itani Y, Kasamatsu Y, Murase S, Sakurada S, Nagano H, Takehara K, Tsuruta T, Arakawa A, Kawano K, Tsubamoto H, Ushiwaka T, Mori T, Iwai K, Saito M, Morisawa H, Saito F, Yoshida K, Kaneuchi M, Sato H, Ito K, Nasu K. Current status of tertiary debulking surgery and prognosis after secondary debulking surgery for recurrent Mﾃｼllerian epithelial cancer in Japan: a retrospective analysis of 164 patients (KCOG-G1402). World J Surg Oncol. 2017 Jul 17;15(1):132. doi: 10.1186/s12957-017-1200-x. PMID: 28716033; PMCID: PMC5512837.
大規模臨床試験の原点は目の前の患者の研究、つまり症例報告に他なりません。
また、大規模臨床試験では明らかにできない、個々の症例に対するエビデンスは現在でも症例報告に頼らざるをえません。
そのため我々は、大規模臨床試験と同様に、症例報告にも力を入れています。
主な発表論文
1. Inoue K, Kai K, Sato S, Nishida H, Hirakawa K, Nasu K, Narahara H. Mixed large and small cell neuroendocrine carcinoma and endometrioid carcinoma of the endometrium with high microsatellite instability: A case report and literature review. SAGE Open Med Case Rep. 2021 Feb 27;9:2050313X21999200. doi: 10.1177/2050313X21999200. PMID: 33738100; PMCID: PMC7934024.
2. Tokumitsu R, Hirakawa T, Yano M, Kirakosyan E, Sato S, Nasu K, Narahara H. A Case of Vaginal Malignant Melanoma Completely Resected by Radical Surgery. Am J Case Rep. 2020 Oct 21;21:e927462. doi: 10.12659/AJCR.927462. PMID: 33085655; PMCID: PMC7588352.
3. Yano M, Aso S, Sato M, Aoyagi Y, Matsumoto H, Nasu K. Pembrolizumab and Radiotherapy for Platinum-refractory Recurrent Uterine Carcinosarcoma With an Abscopal Effect: A Case Report. Anticancer Res. 2020 Jul;40(7):4131-4135. doi: 10.21873/anticanres.14412. PMID: 32620662.
4. Sato M, Yano M, Sato S, Aoyagi Y, Aso S, Matsumoto H, Yamamoto I, Nasu K. Uterine tumor resembling ovarian sex-cord tumor (UTROSCT) with sarcomatous features without recurrence after extended radical surgery: A case report. Medicine (Baltimore). 2020 Mar;99(11):e19166. doi: 10.1097/MD.0000000000019166. PMID: 32176042; PMCID: PMC7220453.
5. Oishi T, Nishida M, Takebayashi K, Nasu K, Narahara H. Small-Cell Carcinoma of the Uterine Cervix Discovered With Quadriplegia Caused by Cervical Spine Metastasis. Clin Med Insights Case Rep. 2020 May 7;13:1179547620920170. doi: 10.1177/1179547620920170. PMID: 32523390; PMCID: PMC7236087.
6. Ito K, Yano M, Ogasawara A, Miwa M, Kozawa E, Yasuda M. A unique uterine cervical "teratocarcinosarcoma": a case report. Diagn Pathol. 2019 Nov 4;14(1):122. doi: 10.1186/s13000-019-0890-5. PMID: 31684979; PMCID: PMC6827231.
7. Yano M, Katoh T, Hamaguchi T, Kozawa E, Hamada M, Nagata K, Yasuda M. Tumor-to-tumor metastasis from appendiceal adenocarcinoma to an ovarian mature teratoma, mimicking malignant transformation of a teratoma: a case report. Diagn Pathol. 2019 Aug 14;14(1):88. doi: 10.1186/s13000-019-0865-6. PMID: 31409389; PMCID: PMC6692929.
8. Yano M, Shintani D, Katoh T, Hamada M, Ito K, Kozawa E, Hasegawa K, Yasuda M. Coexistence of endometrial mesonephric-like adenocarcinoma and endometrioid carcinoma suggests a Mﾃｼllerian duct lineage: a case report. Diagn Pathol. 2019 Jun 7;14(1):54. doi: 10.1186/s13000-019-0830-4. PMID: 31174566; PMCID: PMC6556029.
9. Eto S, Kai K, Nasu K, Nishida M, Nishida H, Narahara H. Small cell carcinoma of the uterine cervix during pregnancy. Rare Tumors. 2019 Aug 1;11:2036361319866539. doi: 10.1177/2036361319866539. PMID: 31413821; PMCID: PMC6676253.
10. Yano M, Asami Y, Nishikawa T, Yoshida S, Kamada K, Katoh T, Teramoto Y, Nakamura Y, Yasuda M. Immune checkpoint inhibitors of CTLA4 and PD-1 for malignant melanoma arising in ovarian cystic teratoma: A case report. Medicine (Baltimore). 2018 Oct;97(43):e12937. doi: 10.1097/MD.0000000000012937. PMID: 30412106; PMCID: PMC6221685.
11. Yano M, Nasu K, Matsumoto H, Hirakawa T, Miyamoto S, Narahara H. Ruptured external iliac artery pseudoaneurysm following surgery for ovarian cancer: A case report and literature review. J Obstet Gynaecol Res. 2018 Jan;44(1):184-186. doi: 10.1111/jog.13475. Epub 2017 Oct 13. PMID: 29027310.
12. Itonaga Y, Nishida M, Matsumoto H, Nasu K, Narahara H. A Case of Neuroendocrine Carcinoma Developing from the Broad Ligament of the Uterus. Rare Tumors. 2017 Jul 3;9(2):6958. doi: 10.4081/rt.2017.6958. PMID: 28975020; PMCID: PMC5617910.
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