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大分大学医学部附属病院薬剤部
 
業　績（原著論文）

原著論文（2020年～）

2025年
　　　　　　
  1. Metabolomic characteristics of cord blood from neonates with hyperkalemia after antenatal exposure to ritodrine and magnesium sulfate. Inoue M, Sekiguchi K, Tsushita H, Inoue N, Maeda T, Itoh H, Ihara K. Sci Rep, 15(1), 2186 (2025)
  2. The active metabolite hydroxyitraconazole has substantially higher in vivo free fraction and free concentrations compared to itraconazole. Iwao M*, Tanaka R*, Suzuki Y, Tatsuta R, Hashimoto T, Hiramatsu K, Itoh H. J Pharm Biomed Anal, 259, 116775 (2025) *Co-1st author
  3. Association of chemotherapy-induced nausea and vomiting or anorexia with plasma levels of five gastrointestinal peptides in patients receiving chemotherapy. Tatsuta R, Tanaka R, Tashibu A, Suzuki Y, Suzuki K, Shibata T, Ando T, Shin T, Sato Y, Itoh H. J Pharm Health Care Sci 11, 17 (2025)
  4. Sensitive quantification of free lenvatinib using ultra-high performance liquid chromatography coupled to tandem mass spectrometry and the clinical significance of measuring free lenvatinib concentration. Sueshige Y*, Shiraiwa K*, Tanaka R, Abe H, Tatsuta R, Saito T, Iwao M, Endo M, Arakawa M, Murakami K, Itoh H. Clin Chim Acta, 569, 120188 (2025) *Co-1st author
  5. Pharmacokinetic variability and significance of therapeutic drug monitoring for broad-spectrum antimicrobials in critically ill patients. Tanaka R. J Pharm Health Care Sci, 11(1), 21 (2025)
  6. Gas-forming abscess associated with prosthetic vascular graft infection caused by Bacteroides fragilis. Iwao M, Hashimoto T, Tanaka R, Hiramatsu K, Itoh H. Braz J Infect Dis, 29, 104524 (2025)
  7. Clinical relevance of immune checkpoint inhibitors for the analgesic effect of opioids: A retrospective propensity score analysis. Sumimoto T, Tanaka R, Murakami Y, Tatsuta R, Itoh H. Br J Clin Pharmacol. in press (2025)
  8. Effect of augmented renal clearance and febrile neutropenia on initial trough level and clearance of teicoplanin. Kondo N*, Tanaka R*, Tatsuta R, Tsushita H, Hashimoto T, Hiramatsu K, Itoh H. Ther Drug Monit, in press (2025) *Co-1st author
  9. Impact of cancer cachexia progression on OATP1B1 transport activity: Quantitative analysis using coproporphyrin-I as an endogenous biomarker. Sumimioto T, Tanaka R, Suzuki Y, Negami J, Sueshige Y, Oda A, Shiraiwa K, Inagaki T, Nishikawa K, Tatsuta R, Otsu S, Ogata M, Ohno K, Itoh H. Clin Pharmacol Ther, in press (2025)
  10. Belatacept pharmacokinetic analysis of Belatacept Early Steroid withdrawal Trial (BEST) to clinical outcomes and compared with reported BENEFIT and BENEFIT-EXT pharmacokinetic analysis. Pyatt A, McGowan M, Tanaka R, Miyagawa B, Mizuno T, Shields AR, Christianson A, West-Thielke P, Leone JP, Woodle ES, Kaufman D, Wiseman A, Matas AJ, Vinks AA, Alloway RR. Clin Transplant, in press (2025)
2024年
　　　　　　
  1. Rapid and simple quantification of belimumab in human plasma using ultra-high performance liquid chromatography with tandem mass spectrometry. Yoshijima C, Suzuki Y, Tanaka R, Ono H, Oda A, Ozaki T, Shibata H, Itoh H, Ohno K. Clin Biochem, 124, 110706 (2024)
  2. Relationship of plasma 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid concentration with OATP1B activity in patients with chronic kidney disease. Ono H, Tanaka R, Suzuki Y, Oda A, Sato H, Tatsuta R, Ando T, Shin T, Ohno K, Itoh H. Clin Transl Sci, 17(3), e13768 (2024)
  3. Usefulness of belimumab in adult patients with systemic lupus erythematosus evaluated using single indexes: a meta-analysis and systematic review. Yoshijima C, Suzuki Y, Oda A, Tanaka R, Ono H, Itoh H, Ohno K. Curr Ther Res Clin Exp, 100, 100738 (2024)
  4. Evaluation of the usefulness of plasma 4β-hydroxycholesterol concentration normalized by 4α-hydroxycholesterol for accurate CYP3A phenotyping. Oda A, Suzuki Y, Sato H, Koyama T, Nakatochi M, Momozawa Y, Tanaka R, Ono H, Tatsuta R, Ando T, Shin T, Wakai K, Matsuo K, Itoh H, Ohno K. Clin Transl Sci, 17(2), e13731 (2024)
  5. Forecasting Fetal Buprenorphine Exposure through Maternal-Fetal Physiologically Based Pharmacokinetic Modeling. van Hoogdalem MW*, Tanaka R*, Abduljalil K, Johnson TN, Wexelblatt SL, Akinbi HT, Vinks AA, Mizuno T. Pharmaceutics, 16(3), 375 (2024) *Co-1st author
  6. Risk factors for teicoplanin-associated acute kidney injury in patients with hematological malignancies: focusing on concomitant use of tazobactam/piperacillin. Morinaga Y, Tanaka R, Tatsuta R, Takano K, Hashimoto T, Ogata M, Hiramatsu K, Itoh H. Biol Pharm Bull, 47(5), 988-996 (2024)
  7. Real-world prevalence and tolerability of immune-related adverse events in older adults with non-small cell lung cancer: A multi-institutional retrospective study. Matsukane Y, Oyama T, Tatsuta R, Kimura S, Hata K, Urata S, Watanabe H. Cancers, 16, 2159 (2024)
  8. Development and verification of a full physiologically-based pharmacokinetic model for sublingual buprenorphine in healthy adult volunteers that accounts for nonlinear bioavailability. van Hoogdalem MW, Tanaka R, Johnson TN, Vinks AA, Mizuno T. Drug Metab Dispos, 52(8), 785-796 (2024)
  9. Evaluation of intra- and inter-individual variations in plasma belimumab concentrations in adult patients with systemic lupus erythematosus. Yoshijima C, Suzuki Y, Tanaka R, Ono H, Oda A, Ozaki T, Shibata H, Itoh H, Ohno K. Pharmacol Res Perspect, 12(4), e1255 (2024)
  10. Lack of interchangeability between three different methods for quantification of everolimus in blood: ACMIA, LTIA, and UHPLC-MS/MS. Miyagi C*, Tanaka R*, Shiraiwa K, Tatsuta R, Itoh H. Ther Drug Monit, 46(6), 717-724 (2024) *Co-1st author
  11. Comparison of Efficacy, Safety, and Economic Outcomes Between Biosimilar ABP 215 and Originator Bevacizumab in Japanese Patients With Colorectal Cancer. Sumimoto T, Tanaka R, Tatsuta R, Kubota M, Itoh H. Cureus, 16(10), e72260 (2024)
  12. Ultra-sensitive quantification of coproporphyrin-I and -III in human plasma using ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. Negami J, Suzuki Y, Sato H, Toyama D, Tanaka R, Ono H, Oda A, Tatsuta R, Ozaki T, Shibata H, Itoh H, Ohno K. ACS Omega,14;9(47):47135-47144(2024)
  13. In vivo systemic evaluation of nasal drug absorption from powder formulations in rats. Tatsuta R, Tanaka A, Ogawara K-i, Higaki K, Furubayashi T, Sakane T. Eur J Pharm Biopharm.10:114612. (2024)
2023年
　　　　　　
  1. UHPLC-MS/MS method for simultaneous quantification of doripenem, meropenem, ciprofloxacin, levofloxacin, pazufloxacin, linezolid and tedizolid in filtrate during continuous renal replacement therapy. Kai M, Tanaka R, Suzuki Y, Goto K, Ohchi Y, Yasuda N, Tatsuta R, Kitano T, Itoh H. J Clin Lab Anal, 37(1), e24815. (2023)
  2. Positive correlation between organic anion transporter 1B function indicated by plasma concentration of coproporphyrin-I and blood concentration of cyclosporin A in real-world patients. Watanabe T, Tanaka R, Suzuki Y, Sato H, Negami J, Yoshijima C, Oda A, Ono H, Tatsuta R, Ohno K, Itoh H. Br J Clin Pharmacol. 89(5), 1672-1681 (2023)
  3. Antimicrobial efficacy evaluations of metronidazole against Clostridioides difficile infection using fecal pharmacokinetic and pharmacodynamic analyses. Tashiro S, Taguchi K, Enoki Y, Matsumoto K. Pharmaceutical Research, 40 (7) 1799–1806 (2023)
  4. A questionnaire survey of prescription preferences and leftover medication conversations: comparisons among kidney disease patients and healthcare professionals. Nakata T, Fukuda A, Ojiro K, Matsuyama K, Masaki T, Itoh H, Shibata H. Cureus, 15(9), e45842 (2023)
  5. Comparison of incidence of hyponatremia between linezolid and vancomycin by propensity score matching analysis. Tanaka R, Morinaga Y, Iwao M, Tatsuta R, Hashimoto T, Hiramatsu K, Itoh H. Biol Pharm Bull, 46(10), 1365-1370 (2023)
  6. Evaluation of effects of indoxyl sulfate and parathyroid hormone on CYP3A activity considering the influence of CYP3A5 gene polymorphisms. Oda A, Suzuki Y, Yoshijima C, Sato H, Tanaka R, Ono H, Tatsuta R, Ando T, Shin T, Itoh H, Ohno K. Br J Clin Pharmacol, 89(12), 3648-3658 (2023)
  7. Oral teicoplanin administration suppresses recurrence of Clostridioides difficile infection: Proof of concept Tanaka Y§, Tashiro S§, Ikegami S, Enoki Y, Taguchi K, Matsumoto K. Anaerobe, 84: 102789(2023)§ These authors contributed equally to this manuscript.
2022年
　　　　　　
  1. High-throughput simultaneous quantification of five azole anti-fungal agents and one active metabolite in human plasma using ultra-high-performance liquid chromatography coupled to tandem mass spectrometry. Tanaka,R, Shiraiwa K, Takano K, Ogata M, Honda S, Yoshida N, Okuhiro K, Yoshida M, Narahara K, Kai M, Tatsuta R, Itoh H. Clin Biochem. 99, 87-96 (2022)
  2. Response to "iPTH is not a significant factor influencing the Tacrolimus C/D ratio". Tanaka R, Suzuki Y, Watanabe H, Fujioka T, Hirata K, Shin T, Ando T, Ono H, Tatsuta R, Mimata H, Maruyama T, Itoh H. Clin Transl Sci. 15(4), 807-808 (2022)
  3. Development of a Sensitive and High-throughput Assay for Simultaneous Quantification of Five Tyrosine Kinase Inhibitors and Two Active Metabolites in Human Plasma Using Ultra-performance Liquid Chromatography Coupled to Tandem Mass Spectrometry. Sumimoto T, Nakahara R, Suzuki Y, Tanaka R, Yoshida N, Ogata M, Itoh H. Ther Drug Monit. 44(3):419-429 (2022)
  4. Exacerbation of cancer pain after administering immune checkpoint inhibitor in a patient taking opioids: A case report. Sumimoto T, Tanaka R, Shiraiwa K, Tatsuta R, Itoh H. J Clin Pharm Ther. 47, 552-555 (2022)
  5. Association of vancomycin trough concentration and clearance with febrile neutropenia in pediatric patients. Amano E, Tanaka R, Ono H, Tatsuta R, Hashimoto T, Hiramatsu K, Itoh H. Ther Drug Monit. 44, 543-551 (2022)
  6. High-Sensitivity and High-Throughput Quantification of Everolimus in Human Whole Blood using Ultra-High-Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry. Miyagi C, Tanaka R, Hirata K, Watanabe T, Tatsuta R, Miyamura S, Itoh H. Ther Drug Monit. 44(5), 633-640 (2022)
  7. Highly sensitive simultaneous quantification of indoxyl sulfate and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid in human plasma using ultra-high performance liquid chromatography coupled with tandem mass spectrometry. Oda A, Suzuki Y, Sato B, Sato H, Tanaka R, Ono H, Ando T, Shin T, Mimata H, Itoh H, Ohno K. J Sep Sci. 45(10), 1672-1682 (2022)
  8. Sensitive UHPLC-MS/MS quantification method for 4β- and 4α-hydroxycholesterol in human plasma for accurate CYP3A phenotyping. Suzuki Y, Oda A, Negami J, Toyama D, Tanaka R, Ono H, Ando T, Shin T, Mimata H, Itoh H, Ohno K. J Lipid Res. 63(3), 100184 (2022)
  9. Cathepsin G-induced malignant progression of MCF-7 cells involves suppression of PAF signaling through induced expression of PAFH1B2. Tanigawa K, Kiriya M, Hayashi Y, Shinden Y, Kijima Y, Natsugoe S, Sumimoto T, Morimoto-Kamata R, Yui S, Hama K, Yokoyama K, Nakamura Y, Suzuki K, Nojiri H, Inoue K, Karasawa K. Biochim Biophys Acta Mol Cell Biol Lipids. Aug;1867(8):159164, (2022)
  10. Sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial-associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report. Tanaka R, Matsumoto A, Tatsuta R, Ando T, Shin T, Mimata H, Itoh H. Clin Case Rep. 10(6), e05914 (2022)
  11. Impact of inflammation on intra-individual variation in trough voriconazole concentration in patients with hematological malignancies. Maeda Y, Tanaka R, Tatsuta R, Takano K, Hashimoto T, Ogata M, Hiramatsu K, Itoh H. Biol Pharm Bull. 45(8), 1084-1090 (2022)
  12. A validated UHPLC-MS/MS method for quantification of total and free tedizolid concentrations in human plasma. Tanaka R, Kai M, Shinohara S, Tatsuta R, Itoh H. J Pharm Biomed Anal, 219, 114929 (2022)
2021年
　　　　　　
  1. High-throughput and wide-range simultaneous determination of linezolid, daptomycin and tedizolid in human plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry. Tanaka R, Kai M, Goto K, Ohchi Y, Yasuda N, Tatsuta R, Kitano T, Itoh H. J Pharm Biomed Anal, 194, 113764 (2021)
  2. Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study. Koyama T, Kuriyama N, Suzuki Y, Saito S, Tanaka R, Iwao M, Tanaka M, Itoh H, Ihara M, Shindo T, Uehara R. Sci Rep, 11(1), 305 (2021)
  3. Simultaneous quantification method for 5-FU, uracil, and tegafur using UPLC-MS/MS and clinical application in monitoring UFT/LV combination therapy after hepatectomy. Shiraiwa K, Suzuki Y, Uchida H, Iwashita Y, Tanaka R, Iwao M, Tada K, Hirashita T, Masuda T, Endo Y, Inomata M, Itoh H. Sci Rep, 11(1), 3132 (2021)
  4. A retrospective test for a possible relationship between linezolid-induced thrombocytopenia and hyponatremia. Tanaka R, Suzuki Y, Morinaga Y, Iwao M, Takumi Y, Hashinaga K, Tatsuta R, Hiramatsu K, Kadota J, Itoh H. J Clin Pharm Ther, 46(2), 343-351 (2021)
  5. Significant elevation of free itraconazole concentration at onset of adverse effects: a case report. Tanaka R, Suzuki Y, Matsumoto H, Yamasue M, Umeki K, Hashinaga K, Tatsuta R, Hiramatsu K, Kamei K, Kadota J, Itoh H. Clin Case Rep, 9(3), 1187-1192 (2021)
  6. Effect of S-1 on blood levels of phenobarbital and phenytoin: A case report. Shiraiwa K, Ono H, Tanaka R, Fujinaga A, Hiratsuka T, Tatsuta R, Inomata M, Itoh H. Clin Case Rep, 9(3):1514-1517 (2021)
  7. Development of a High-Throughput Quantification Method for Pazopanib Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry and Its Clinical Application in Patients with Soft Tissue Tumors. Shiraiwa K, Suzuki Y, Tanaka K, Kawano M, Iwasaki T, Matsumoto A, Tanaka R, Tatsuta R, Tsumura H, Itoh H. Ther Drug Monit. 43:416-421 (2021)
  8. A broad range high-throughput assay for lenvatinib using ultra-high performance liquid chromatography coupled to tandem mass spectrometry with clinical application in patients with hepatocellular carcinoma. Sueshige Y, Shiraiwa K, Honda K, Tanaka R, Saito T, Tokoro M, Iwao M, Endo M, Arakawa M, Tatsuta R, Murakami K, Itoh H. Ther Drug Monit. 43(5):664-671 (2021)
  9. Simultaneous quantification of plasma levels of 12 antimicrobial agents including carbapenem, anti-methicillin-resistant Staphylococcus aureus agent, quinolone and azole used in intensive care unit using UHPLC-MS/MS method. Kai M, Tanaka R, Suzuki Y, Goto K, Ohchi Y, Yasuda N, Tatsuta R, Kitano T, Itoh H. Clin Biochem, 90, 40–49 (2021)
  10. Pharmacokinetic and adsorptive analyses of administration of oral voriconazole suspension via enteral feeding tube in intensive care unit patients. Tanaka R, Eto D, Goto K, Ohchi Y, Yasuda N, Suzuki Y, Tatsuta R, Kitano T, Itoh H. Biol Pharm Bull, 44(5), 737-741 (2021)
  11. Sensitive, wide-range and high-throughput quantification of cyclosporine in whole blood using ultra-performance liquid chromatography coupled to tandem mass spectrometry and comparison with an antibody-conjugated magnetic immunoassay. Watanabe T, Tanaka R, Ono H, Suzuki Y, Tatsuta R, Itoh H. Biomed Chromatogr, 35(8), e5128 (2021)
  12. Association of CYP3A5 polymorphisms and parathyroid hormone with blood level of tacrolimus in patients with end-stage renal disease. Tanaka R, Suzuki Y, Watanabe H, Fujioka T, Hirata K, Shin T, Ando T, Ono H, Tatsuta R, Mimata H, Maruyama T, Itoh H. Clin Transl Sci, 14(5), 2034-2042 (2021)
  13. Successful determination of imatinib re-administration dosage by therapeutic drug monitoring in a case of chronic myeloid leukemia initiating dialysis for acute renal dysfunction.　Nakahara R, Sumimoto T, Tanaka R, Ogata M, Itoh H. Clinical Case Reports. Clin Case Rep, 9(8):4357-4361 (2021)
  14. Factors influencing plasma coproporphyrin-I concentration as biomarker of OATP1B activity in patients with rheumatoid arthritis. Ono H, Tanaka R, Suzuki Y, Oda A, Ozaki T, Tatsuta R, Maeshima K, Ishii K, Ohno K, Shibata H, Itoh H. Clin Pharmacol Ther, 110(4), 1096-1105 (2021)
  15. Sensitive quantification of free pazopanib using ultra-high performance liquid chromatography coupled to tandem mass spectrometry and assessment of clinical application. Matsumoto A, Shiraiwa K, Suzuki Y, Tanaka K, Kawano M, Iwasaki T, Tanaka R, Tatsuta R, Tsumura H, Itoh H. J Pharm Biomed Anal. 206, 114348 (2021)
  16. Maximum plasma concentration of lenvatinib is useful for predicting thrombocytopenia in patients treated for hepatocellular carcinoma. Endo M, Honda K, Saito T, Shiraiwa K, Sueshige Y, Tokumaru T, Iwao M, Tokoro M, Arakawa M, Tanaka R, Tatsuta R, Seike M, Itoh H, Murakami K. World J Oncol. 12(5), 165-172 (2021)
  17. Association between MR-proADM concentration and treatment intensity of antihypertensive agents in chronic kidney disease patients with insufficient blood pressure control. Iwao M, Tanaka R, Suzuki Y, Nakata T, Aoki K, Fukuda A, Fukunaga N, Tatsuta R, Ohno K, Shibata H, Itoh H. Sci Rep. 11(1), 21931 (2021)
  18. A case of improvement of clozapine-induced low leukocyte counts by adenine, cepharanthin and ninjin-yoei-to in a patient with treatment-resistant schizophrenia. Kamei S, Tanaka R, Hirakawa H, Iwao M, Kawanaka R, Tatsuta R, Terao T, Itoh H. J Pharm Health Care Sci. 7(1), 45 (2021)
2020年
　　　　　　
  1. Pharmacokinetic and toxicodynamic evaluation of 5-fluorouracil administration after major hepatectomy in a rat model. Tada K, Iwashita Y, Shiraiwa K, Uchida H, Oshima Y, Sato Y, Nakanuma H, Hirashita T, Masuda T, Endo Y, Takeuchi Y, Ohta M, Itoh H, Inomata M. Cancer Chemotherapy and Pharmacology, 85(2), 345-352 (2020)
  2. Venous thromboembolisms and rheology in ovarian cancer patients after postoperative adjuvant paclitaxel and carboplatin therapy. Suzuki K, Sato Y, Nakahara R, Tatsuta R, Tanaka R, Itoh H. Pharmazie, 75(5), 205-207 (2020)
  3. Sensitive and selective quantification of mid-regional proadrenomedullin in human plasma using ultra-performance liquid chromatography coupled with tandem mass spectrometry. Iwao M, Suzuki Y, Tanaka R, Koyama T, Ozaki E, Nakata T, Aoki K, Fukuda A, Sato Y, Kuriyama N, Fukunaga N, Sato F, Katagiri F, Ohno K, Shibata H, Mimata H, Itoh H. J Pharm Biomed Anal. 183, 113168 (2020)
  4. Simultaneous quantification of coproporphyrin-I and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid in human plasma using ultra-high performance liquid chromatography coupled to tandem mass spectrometry. Suzuki Y, Sasamoto Y, Yoshijima C, Tanaka R, Ono H, Ando T, Shin T, Mimata H, Itoh H, Ohno K. J Pharm Biomed Anal. 184, 113202 (2020)
  5. Changes in redox state of albumin before and after kidney transplantation in patients with end-stage renal disease. Tanaka R, Imafuku T, Suzuki Y, Nishida K, Matsusaka K, Shin T, Sato Y, Ishima Y, Watanabe H, Mimata H, Maruyama T, Itoh H. Clin Biochem, 81, 20-26 (2020)
  6. In vivo evaluation of drug dialyzability in a rat model of hemodialysis. Fukunaga M, Kadowaki D, Mori M, Hagiwara S, Narita Y, Saruwatari J, Tanaka R, Watanabe H, Yamasaki K, Taguchi K, Ito H, Maruyama T, Otagiri M, Hirata S. PLoS One, 15(6), e0233925 (2020)
  7. Effects of dose and type of corticosteroids on the divergence between estimated glomerular filtration rates derived from cystatin c and creatinine. Tsushita H, Tanaka R, Suzuki Y, Sato Y, Itoh H. J Clin Pharm Ther, 45(6), 1390-1397 (2020)
  8. A prospective study on the usefulness of initial voriconazole dose adjustment based on CYP2C19 gene polymorphism analysis. Tanaka R, Fujioka T, Suzuki Y, Iwao M, Itoh H. Chemotherapy, 65(3-4):59-64 (2020)
  9. Population pharmacokinetic analysis of doripenem for Japanese patients in intensive care unit. Nonoshita K, Suzuki Y, Tanaka R, Kaneko T, Ohchi Y, Sato Y, Yasuda N, Goto K, Kitano T, Itoh H. Sci Rep, 10(1), 22148 (2020)