1.
Kubo S, Ninomiya R, Kajiwara T, Tokunaga A,
Matsuda S, Murakami K, Yamaoka Y, Aigaki T, Hamada
F.：Helicobacter
pylori virulence factor CagA promotes Snail-mediated
epithelial-mesenchymal transition and invasive behavior by downregulating Semaphorin 5A in gastric epithelial cells. Biochem Biophys Res
Commun. 2025 Mar 1:750:151421.2025.
2. Yamamiya
K, Li X, Nabeka H, Khan S, Khan F, Wakisaka H, Saito
S, Hamada F, Matsuda S: Tracking of Prosaposin, a Saposin
Precursor, in Rat Testis. J Histochem Cytochem. 71(10):537-554, 2023.
3. Khan S, Takeuchi A, Nabeka H, Khan F, Shimokawa T, Takanezawa
S, Saitou T, Imamura T, Tachibana T, Nishizono A, Hamada F,
Matsuda S: Administration of prosaposin-derived neurotrophic factor toneural tube defects facilitatesregeneration
and restoresneurological functions. iScience 26, 2023.
4. Dong
X, Chiba S,Shimada T, Hamada
F: A Statistical Evaluation of Uncoupling Protein 1 in the Limited Area of
Brown Adipose Tissue by Immunoelectron Microscopy. Computational Chemistry
10, 121-137, 2022.
5. Kawashima
T, Ji RC, Itoh Y, Agata N, Sasai N, Murakami T, Sokabe M, Hamada F, Kawakami K: Morphological and
biochemical changes of lymphatic vessels in the soleus muscle of mice after
hindlimb unloading. Muscle Nerve 64(5), 620-628, 2021.
6. Abe
M, Miura M, Hamada F, Sugio K.
: Arterial blood supply patterning of the mammary sentinel lymph nodes
with special reference to the relation of the formation mechanism of the
superficial subscapular artery. Anat Sci Int 96, 489-508, 2021.
7. Taniguchi
M, Nabeka H, Yamamiya K, Khan MSI, Shimokawa T, Islam
F, Doihara T, Wakisaka H, Kobayashi N, Hamada F, Matsuda S.: The
expression of prosaposin and its receptors, GRP37 and GPR37L1, are increased in
the developing dorsal root ganglion. PLoS
One 16, e0255958, 2021.
8. Ninomiya
R, Kubo S, Baba T, Kajiwara T, Tokunaga A, Nabeka H,
Doihara T, Shimokawa T, Matsuda S, Murakami K, Aigaki
T, Yamaoka Y, Hamada F: Inhibition of low-density lipoprotein uptake by
Helicobacter pylori virulence factor CagA. Biochem. Biophys. Res.Commun. 556, 192-198, 2021.
9. Kunihiro
J, Nabeka H, Wakisaka H, Unuma
K, Khan MSI, Shimokawa T, Islam F, Doihara T, Yamamiya K, Saito S, Hamada F,
Matsuda S.:Prosaposin and
its receptors GRP37 and GPR37L1 show increased immunoreactivity in the facial
nucleus following facial nerve transection.PLoS
One. 15(12), e0241315, 2020.
10.
Iwasaki K, Ninomiya R, Shin T, Nomura
T, Kajiwara T, Hijiya N, Moriyama M, MimataH, Hamada F.: Chronic hypoxia-induced slug
promotes invasive behavior of prostate cancer cells by activating expression of
ephrin-B1. Cancer Sci. 109 (10), 3159-3170, 2018.
11.
Nabeka H,
Saito S, Li X, Shimokawa T, Md. Sakirul Islam Khan,
Yamamiya K, Kawabe S, Doihara T, Hamada F, Kobayashi N, Matsuda S.:
Interneurons secrete prosaposin, a neurotrophic factor, to attenuate kainic
acid-induced neurotoxicity.IBRO
Reports 3, 17-32, 2017.
12.
Khan MSI, Nabeka
H, IslamF, Shimokawa T, Saito S, LiX,
Kawabe S, Hamada F, Tachibana T, Matsuda S.: Early neonatal loss of inhibitorysynaptic input to the spinal motor neurons
confers spina bifida-like leg dysfunction in a chicken model. Dis Model
Mech. 10(12), 421-1432, 2017.
13.
Nabeka H,
Shimokawa T, Doihara T, Saito S, Wakisaka H, Hamada F, Kobayashi N,
Matsuda S.: A prosaposin-derived Peptide alleviates kainic Acid-induced brain
injury. PLoS One. 10(5), e0126856,2015.
14.
Li C, Gao, HL, Shimokawa T, Nabeka H, Hamada F, Araki H, Cao YM, Kobayashi N,
Matsuda S: Prosaposin expression in the regenerated muscles of mdx and
cardiotoxin-treated mice. Histol. Histopathol. 28 (7), 875-892, 2013.
15.
Taniue K,
Nishida A, Hamada F, Sugie A, Oda T, Ui-Tei K,
Tabata T, Akiyama T: Sunspot, a link between Wingless signaling and
endoreplication in Drosophila. Development 137, 1755-1764, 2010.
16.
Miguchi Y,
Takata H, Doihara T, Miyawaki K, Shimokawa T, Hamada F, Kobayashi N,
Matsuda S: Morphological maturation level of the esophagus is associated with
the number of circumesophageal muscle fibers during
archenteron formation in the starfish Patiria (Asterina) pectinifera. Biol.
Bul. l219, 12-6, 2010.
17.
Matsuda S, Hamada F, Ishizuka
N: The Structure of Dendritic Spines in Dendritic Spines: Biochemistry,
Modeling and Properties, pp151-162, NOVA Science publisher(2009)
18.
Doihara T, Miguchi,
Y, Miyawaki K, Shimokawa T, Hamada F, Kobayashi N, Matsuda S:
Spatiotemporal distribution patterns of oligosaccharides during early
embryogenesis in the starfish Patiria pectinifera. Dev. Genes. Evol. 219, 199-206, 2009.
19.
Tran, H, Hamada F,
Schwarz-Romond T, Bienz M: Trabid, a new positive
regulator of Wnt-induced transcription with
preference for binding to and cleaving K63-linked ubiquitin chains. Genes
Dev 22, 528-542, 2008.
20.
Hosoda Y, Miyawaki K, Saito S, Chen J,
Bing X, Terashita T, Kobayashi N, Araki N, Shimokawa T, Hamada F, Sano
A, Tanabe H, Matsuda S: Distribution of prosaposin in the rat nervous system. Cell
Tissue Res. 330, 197-207, 2007.
21.
Hamada F & Bienz
M: The APC tumor suppressor binds to C-terminal binding protein to divert
nuclear b-catenin from TCF. Dev. Cell 7, 677-685, 2004.
22.
Bienz M. & Hamada F: Adenomatous
polyposis coli proteins and cell adhesion. Curr. Opin.
Cell Biol. 16, 528-535, 2004.
23.
Cliffe A, Hamada F, Bienz M: A
role of Dishevelled in relocating Axin
to the plasma membrane during Wingless signaling. Curr. Biol. 13,
960-966, 2003.
24.
Hamada F. & Bienz
M: A Drosophila APC tumour suppressor homolog
functions in cellular adhesion. Nat. Cell Biol. 4, 208-213, 2002.
25.
Haraguchi K, Satoh K, Yanai H, Hamada
F, Kawabuchi M, Akiyama T: The hDLG-associated protein DAP interacts with dynein light
chain and neuronal nitric oxide synthase. Genes Cells. 5, 905-912, 2000.
26.
Kawahara K, Morishita T, Nakamura T, Hamada
F, Toyoshima K, Akiyama T: Down-regulation of b-catenin by the colorectal
tumor suppressor APC requires association with Axin
and b-catenin. J. Biol. Chem. 275, 8369-8374, 2000.
27.
Hamada F, Murata Y,
Nishida A, Fujita F, Tomoyasu Y, Nakamura M, Toyoshima K, Tabata T, Ueno N,
Akiyama T: Identification and characterization of E-APC, a novel Drosophila
homologue of the tumor suppressor APC. Genes Cells. 4, 465-474, 1999.
28.
Hamada F, Tomoyasu Y,
Takatsu Y, Nakamura M, Nagai S, Suzuki A, Fujita F, Shibuya H, Toyoshima K,
Ueno N, Akiyama T: Negative regulation of Wingless signaling by D-Axin, a Drosophila homolog of Axin.
Science 283, 1739 - 1742, 1999.
29.
Nakamura T, Hamada F, Ishidate T, Anai K, Kawahara K, Toyoshima K, Akiyama T: Axin, an inhibitor of the Wnt signalling pathway, interacts with -catenin, GSK-3 b and
APC and reduces the b -catenin level. Genes Cells 3, 395-403, 1998.
30.
Bhattacharjee, R. N, Hamada F,
Toyoshima K, Akiyama T: The tumor suppressor gene product APC is
hyperphosphorylated during the M phase. Biochem.
Biophys. Res. Commun. 220, 192-195, 1996.
31.
Hitsumoto Y,
Song D. S, Okada M, Hamada F, Saheki S, Takeuchi N: Enhancement of
CD3-mediated thymocyte apoptosis by the cross-linkage of heat-stable antigen. Immunology
89, 200-204, 1996.
32.
Hamada F, Aoki M,
Akiyama T, Toyoshima K: Association of immunoglobulin G Fc receptor II with Src-like protein tyrosine kinase Fgr
in neutrophils. Proc. Natl. Acad. Sci. USA 90, 6305-6309, 1993.
33.
Aoki M, Hamada F, Sugimoto T,
Sumida S, Akiyama T, Toyoshima K: The human cot proto-oncogene encodes two
protein serine/threonine kinases with different transforming activities by
alternative initiation of translation. J. Biol. Chem. 268, 22723-22732,
1993.
34.
Hitsumoto Y,
Ohnishi H, Nakano A, Hamada F, Saheki S, Takeuchi N: Inhibition of
homologous complement activation by the heat-stable antigen. Int. Immunol.
5, 805-808, 1993.
35.
Hitsumoto Y,
Nakano A, Ohnishi H, Hamada F, Saheki S, Takeuchi N: Purification of the
murine heat-stable antigen from erythrocytes. Biochem.
Biophys. Res. Commun. 187, 773-777, 1992.
1. Dong
X, Chiba S, Shimada T, Hamada F: A Statistical Evaluation of Uncoupling
Protein 1 in the Limited Area of Brown Adipose Tissue by Immunoelectron
Microscopy. Computational Chemistry 10, 121-137, 2022.
2. 酒井久美子、千葉政一、西内美香、駒井三千夫: 亜鉛を軸にした新しい代謝経路の解析方法. Medical Science Digest
47巻3月号(通巻618号)2021.
3. Yan
Q, Ina K, Chiba S, Wei H, Tatsukawa S,Fujikura Y.: The signal pathway
for the repressive effect of dipyridamole on myofibroblast transdifferentiation.
J Cell Mole Med. 23(2),1608-1612, 2019.
4. Ando
H, Gotoh K, Fujiwara K, Anai M, Chiba S, Masaki T, Kakuma T, Shibata H:
Glucagon-like peptide-1 reduces pancreatic beta-cell mass through hypothalamic
neural pathways in high-fat diet-induced obese rats. Sci Rep 7:5578,
2017.
5. 千葉政一：基礎医学研究の今。肥満研究 68(2):130-131, 2017.
6. 千葉政一、森脇千夏、伊奈啓輔、藤倉義久：摂食と肥満における視床下部神経ヒスタミンの役割:創薬へ向けて。日本薬理学会雑誌 147:1-8, 2016 .
7. 大隈まり、千葉政一 、中原 成浩：脳神経外科治療と食行動異常を伴う代謝性疾患群 (それぞれの診療科における肥満症の問題点) . 日本肥満学会誌 21(3), 149-154, 2015 .
8. Ando
H, Gotoh K, Fujiwara K, Anai M, Chiba S, Masaki T, Kakuma T, Shibata H:
Glucagon-like peptide-1 reduces pancreatic beta-cell mass through hypothalamic
neural pathways in high-fat diet-induced obese rats. Sci Rep 7:5578,
2017.
9. 佐藤文憲、安藤忠助、澁谷忠正、佐藤竜太、秦
聡孝、森 健一、野村威雄、三股浩光、正木孝幸、後藤孔郎、千葉政一、柴田洋孝:当科における生体腎移植ドナーのbody mass indexと周術期成績に関する検討 (シンポジウム 腎移植,更なる成績の向上のために．技術の進歩と応用によるハイリスク症例への対応) 。西日本泌尿器科
(The Nishinihon journal of urology）78(6):277-283, 2016.
10.
Aosa T,
Chiba S, Kitamura H, Ina K, Tatsukawa S,
Moriwaki C, Wei H, Gotoh K, Masaki T, Kakuma T, Shibata H, Fujikura Y: Pore
alterations of the endothelial lining of rat fenestrated intestinal capillaries
exposed to acute stress. Histol. Histopathol. 31(7):807-817, 2016.
11.
Moriwaki C, Chiba S, Wei H, Aosa T, Kitamura H, Ina K, Shibata H, Fujikura Y:
Distribution of histaminergic neuronal cluster in the rat and mouse hypothalamus.J Chem Neuroanat 68:1-13, 2015.
12.
Wei H, Chiba S, Moriwaki C,
Kitamura H, Ina K, Aosa T, Tomonari
K, Gotoh K, Masaki T, Katsuragi I, Noguchi H, Kakuma
T, Hamaguchi K, Shimada T, Fujikura Y, Shibata H: A clinical approach to brown
adipose tissue in the para-aortic area of the human thorax. PloS
one 10:e0122594, 2015.
13.
Mitsutomi K,
Masaki T, Shimasaki T, Gotoh K, Chiba S, Kakuma T, Shibata H: Effects of
a nonnutritive sweetener on body adiposity and energy metabolism in mice with
diet-induced obesity. Metabolism 63:69-78, 2014
14.
Kakuma T, Chiba S, Takahashi Y,
Kai K, Tsubone T. Yoshimatsu H: Self-weighing
contributes to glycemic control: importance of measuring body weight. Diabetol Int 4, 40-44, 2013
15.
Gotoh K, Inoue M, Masaki T, Chiba S,
Shiraishi K, Shimasaki T, Matsuoka K, Ando H, Fujiwara K, Fukunaga N, Aoki K, Nawata T, Katsuragi I, Kakuma T, Seike M, Yoshimatsu HGotoh K,
Inoue M, Masaki T, Chiba S, Shiraishi K, Shimasaki T, Matsuoka K, Ando H,
Fujiwara K, Fukunaga N, Aoki K, Nawata T, Katsuragi I, Kakuma T, Seike M,
Yoshimatsu H: Obesity-related chronic kidney disease is associated with
spleen-derived IL-10. Nephrol Dial Transplant 28:1120-1130, 2013.
16.
Gotoh K, Masaki T, Chiba S, Ando H, Fujiwara K, Shimasaki T, Mitsutomi K, Katsuragi I, Kakuma
T, Sakata T, Yoshimatsu H: Hypothalamic brain-derived neurotrophic factor
regulates glucagon secretion mediated by pancreatic efferent nerves. J Neuroendocrinol 25:302-311, 2013.
17.
Gotoh K, Masaki T, Chiba S,
Ando H, Fujiwara K, Shimasaki T, Mitsutomi K, Katsuragi I, Kakuma T, Sakata T, Yoshimatsu H:
Brain-derived neurotrophic factor, corticotropin-releasing factor, and
hypothalamic neuronal histamine interact to regulate feeding behavior. J
Neurochem 125:588-598, 2013.
18.
Gotoh K, Masaki T, Chiba S,
Ando H,Shimasaki T, Mitsutomi K, Fujiwara K, Katsuragi
I, Kakuma T, Sakata T, Yoshimatsu H: Nesfatin-1, corticotropin-releasing
hormone, thyrotropin-releasing hormone, and neuronal histamine interact in the
hypothalamus to regulate feeding behavior. J Neurochem
124:90-99, 2013.
19.
Shimasaki T, Masaki T, Mitsutomi K, Ueno D, Gotoh K, Chiba S, Kakuma T,
Yoshimatsu H: The dipeptidyl peptidase-4 inhibitor des-fluoro-sitagliptin
regulates brown adipose tissue uncoupling protein levels in mice with
diet-induced obesity. PloS one 8:e63626, 2013.
20.
Ueno D, Masaki T, Gotoh K, Chiba S,
KakumaT, Yoshimatsu H: Cilnidipine regulates glucose
metabolism and levels of high-molecular adiponectin in diet-induced obese mice.
Hypertens Res 36:196-201, 2013.