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| Associate Professor |
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Noritaka Matsuo |
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| Research Projects | ： | 1) Analysis of the function of extracellular matrix molecules, especially collagen
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tissues and organs in the organisms are formed and maintained by the
interaction between various cells and the surrounding extracellular
matrix. It is important to understand the roles of the extracellular
matrix as well as the cells in order to elucidate the mechanisms in the
physiological and pathological conditions of an organism. Specifically,
we are focusing on the regulation of collagen genes and their functions. | | | | | | 2) Search for the new substances in natural materials and the analysis of their biological function | | | | | | There
are many natural substances. Some of them have a biological function
for maintaining the homeostasis of the individual. Apart from drugs,
those substances maintain and improve the individual’s daily health
conditions. We are focusing on identifying new substances and
elucidating their functions. | | | | | | 3) Search for tissue specific differentiation factors in mesenchymal stem cells and the analysis of their function | | | | | | The
cells in bone, cartilage, skin, muscle and fat are differentiated from
mesenchymal stem cells. The mechanisms for their differentiation remain
unclear in spite of extensive study. The extracellular matrix is
involved in some steps of these mechanisms. We are therefore focusing
on identifying the factors can eventually be applied for use in the
field of regenerative medicine. |
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| |  | | | | 1) | N. Matsuo,
S. Tanaka, H. Yoshioka, M. Koch, M. K. Gordon, F. Ramirez. Collagen
XXIV (Col24a1) gene expression is a specific marker of osteoblast
differentiation and bone formation. Connective tissue Res. 49, 68-75,
2008 |  | | | | | 2) | N. Matsuo,
S. Tanaka, M. K. Gordon, M. Koch, H. Yoshioka, F. Ramirez. CREB/AP1
protein complexs regulate transcription of the collagen XXIV gene
(Col24a1) in osteoblasts. J. Biol. Chem. 281; 5445-52; 2006 (IF: 5.581) | | | | | | 3) | K. Yamaguchi, N. Matsuo,
H Sumiyoshi, N Fujimoto, K Iyama, H Yoshioka. Pro-α3(V) collagen chain
is expressed in bone and its basic N-terminal peptide adheres to
osteosarcoma cells. Matrix Biol. 24: 283-294, 2005 (IF: 3.687) | | | | | | 4) | H. Nagato, N. Matsuo,
H. Sumiyoshi, K. Sakata-Takatani, M. Nasu, H. Yoshioka. The
transcription factor CCAAT-binding factor CBF/NF-Y and two repressors
regulate the core promoter of the human pro-α3(V) collagen gene (COL5A3). J. Biol. Chem. 279; 46373-83; 2004 (IF: 5.581) | | | | | | 5) | K. Sakata, N. Matsuo,
H. Sumiyoshi, T. Tsuda, H. Yoshioka. Identification of a functional
CBF-binding CCAAT-like motif in the core promoter of the mouse pro-α1(V) collagen gene (Col5a1). Matrix Biol. 23: 87-99, 2004 (IF: 3.687) | | | | | | 6) | K. Kimoto, K. Nakatsuka, N. Matsuo,
H. Yoshioka. p38 MAPK mediates the expression of type I collagen
induced by TGF-b2 in human retinal pigment epithelial cells ARPE-19.
Invest. Ophthalmol. Vis. Sci. 45: 2431-2437, 2004 (IF: 3.528) | | | | | | 7) | N. Matsuo,
W. Yu-Hua, H. Sumiyoshi, K. Sakata-Takatani, H. Nagato, K. Sakai, M.
Sakurai, H. Yoshioka. The Transcription factor CCAAT-binding factor
CBF/NF-Y regulates the proximal promoter activity in the human α1(XI) collagen gene (COL11A1). J. Biol. Chem. 278; 32763 - 70; 2003 (IF: 5.581) | | | | | | 8) | R. Kawano, N. Matsuo,
H. Tanaka, M. Nasu, H. Yoshioka, K. Shirabe. Identification and
characterization of a soluble cadherin-7 isoform produced by
alternative splicing. J. Biol. Chem. 277; 47679-85; 2002 (IF: 5.581) | | | | | | 9) | S. Fujiwara, N. Takeo, Y. Otani, D.A.D. Parry, M. Kunimatsu, R. Lu, M. Sasaki, N. Matsuo,
M. Khaleduzzaman, H. Yoshioka. Epiplakin, a novel member of the plakin
family originally identified as a 450-kDa human epidermal autoantigen:
Structure and tissue localization. J. Biol. Chem. 276; 13340-7; 2001
(IF: 5.581) | | | | | | 10) | N. Matsuo,
K. Yamada, M. Mori, K. Shoji, T. Ueyama, S. Yunoki, K. Yamashita, M.
Sugano. Inhibition by dietary tea polyphenols of chemical mediator
release from rat peritoneal exudate cells. Biosci. Biotechnol. Biochem.
64: 1437-1443, 2000 (IF: 1.247) | | | | | | 11) | N. Matsuo,
K. Yamada, K. Shoji, M. Mori, M. Sugano. Effect of tea polyphenols on
histamine release from rat basophilic leukemia (RBL-2H3) cells: The
structure-inhibitory activity relationship. Allergy 52: 58-64, 1997
(IF: 5.014) |
| | | | | 12) | N. Matsuo, K. Osada, T. Kodama, B.O. Lim, A. Nakao, K. Yamada, M. Sugano M.
Effects
of g-linolenic acid (6,9,12-18:3) and its positional isomer
(5,9,12-18:3) on immune parameters of Brown Norway rats. Prostag.
Leukotr. Ess. 55: 223-229, 1996 (IF: 2.000) | | | | | | 13) | N. Matsuo,
K. Yamada, K. Yamashita, K. Shoji, M. Mori, M. Sugano. Inhibitory
effect of tea polyphenols on histamine and leukotriene B4 release from
rat peritoneal exudate cells. In Vitro Cell. Dev. Biol. 32: 340-344,
1996 |
| | | | | 14) | N. Matsuo, K. Yamada, S. Noda, K. Yamashita, A. Okuda, G. Kimura, M. Sugano.
Reversible
proliferation arrest of rat 3Y1 fibroblasts and selective of Simian
virus transformed derivation of 3Y1 by short-chain fatty acids. Int. J.
Oncol. 5: 655-660, 1994 (IF: 2.295) |
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