本文彦の略歴
国際保健部門のスタッフ （更新日2005年5月12日）
部門主任・川本 文彦
川本文彦の略歴
1970年3月 京都工芸繊維大学繊維学部卒業
1974年4月 名古屋大学大学院医学研究科医動物学入学
1978年3月 名古屋大学大学院医学研究科医動物学修了
1978年4月 名古屋大学医学部医動物学講座助手
1985年11月 名古屋大学医学部医動物学講座講師
1998年4月 名古屋大学医学部国際保健医療学講座助教授
2003年9月 大分医科大学教授
2003年10月 大分大学医学部教授
現在の主たる研究課題
【課題名】マラリアとＧ６ＰＤ欠損症の分子疫学的研究
【キーワード】マラリア，Ｇ６ＰＤ欠損症，東南アジア，迅速診断，分子疫学
これまでの国際保健に関する活動
1）東南アジアにおけるマラリアとG6PD欠損症の分子疫学的解析
2）スマトラ沖大地震・津波被害を受けたインドネシア・アチェ州での医療支援活動
3) 海外出張記録
ご意見・ご感想はこちらから
1990年以降の発表論文 ＜原著＞
F. Kawamoto, R. Alejo-Blanco, S.L. Fleck, Y. Kawamoto, R.E. Sinden: Possible roles of Ca2+ and cGMP as mediators of the exflagellation of Plasmodium berghei and Plasmodium falciparum. Mol. Biochem. Parasitol., 42: 101-108, 1990
F. Kawamoto: Rapid diagnosis of malaria by fluorescence microscopy with light microscope and interference filter. Lancet, 337: 200-202, 1991
F. Kawamoto: Rapid diagnosis of malaria by fluorescence microscopy. Lancet, 337: 624-625, 1991
H. Ohmae, F. Kawamoto, A. Ishii, L. Jasson, K. Natan: Detecting splenomegaly by ultrasound. Lancet, 338: 826-827, 1991
F. Kawamoto: Rapid detection of Plasmodium by a new thick smear's method using transmission fluorescence microscopy: direct staining with acridine orange. J. Protozool. Res., 1: 27-34, 1991
F. Kawamoto, R. Alejo-Blanco, S.L. Fleck, R.E. Sinden: Plasmodium berghei: Ionic regulation and the induction of gametogenesis. Exp. Parasitol., 72: 33-42, 1991
Syafruddin, R. Arakawa, K. Kamimura, F. Kawamoto: Penetration of the mosquito midgut wall by the ookinetes of Plasmodium yoeli nigeriensis. Parasitol. Res., 77: 230-236, 1991
F. Kawamoto, N. Kido, T. Hanaichi, M.B.A. Djamgoz, R.E. Sinden: Gamete development in Plasmodium berghei regulated by ionic exchange mechanisms. Parasitol. Res., 78: 277-284, 1992
Syafruddin, R. Arakawa, K. Kamimura, F. Kawamoto: Development of Plasmodium berghei ookinetes to young oocysts in vitro. J. Protozool., 39: 333-338, 1992 Y. Kawamoto, L.A. Winger, K. Hong, H. Matsuoka, Y. Chinzei, F. Kawamoto, K. Kamimura, R. Arakawa, R.E. Sinden, A. Ishii: Plasmodium berghei: Sporozoites are sensitive to human serum but not susceptible host serum. Exp. Parasitol., 75: 361-368, 1992
H. Matsuoka, K. Ando, Y. Chinzei, Y. Kawamoto, F. Kawamoto, R. Arakawa, K. Kamimura, A. Ishii: Cyclical transmission of Plasmodium berghei by Anopheles omorii, Sakakibara 1959 (Diptera: Culicidae). J. Med. Entomol., 29: 343-345, 1992
Syafruddin, K. Kamimura, H. Hasegawa, T. Toma, I. Miyagi, F. Kawamoto, I.J. Nainggolan, M. Tumewu- Wagey, Mandagiwaworuntu, F.X. Kapojos, J. Runtuwene: Epidemiological study of malaria in North Sulawesi, Indonesia by fluorescence and Giemsa staining. Jpn. J. Med. Sci. Biol., 45:175-184,1992
F. Kawamoto: Ionic regulation and signal transduction system involved in the induction of gametogenesis in malaria parasites. Ann. N. Y. Acad. Sci., 707: 431-434, 1993
F. Kawamoto, H. Fujioka, R. Murakami, Syafruddin, M. Hagiwara, T. Ichikawa, H. Hidaka: The roles of Ca2+/calmodulin- and cGMP-dependent pathways in gametogenisis of rodent malaria parasite, Plasmodium berghei. Eur. J. Cell Biol., 60: 101-107, 1993
M. Arai, K. Kunisada, H. Kim, H. Miyake, C. Mizukoshi, T. Kakutani, S. Yamane, S. Nakagami, S. Kawai, H. Nakano, F. Kawamoto, Y. Wataya: A colorimetric DNA diagnostic method for falciparum and vivax malaria: A field trial in the Solomon Islands. Nucleotides & Nucleosides, 15: 719-731, 1996
S. Shinonaga, F. Kawamoto, S. Mizuno, A. Akutagawa, Y. Hiraoka: Two cases of cutaneous myiasis due to Dermatobia hominis (Diptera,cuterebridae) imported into Japan. Jpn. J. Sanit. Zool., 45: 147-151, 1 1996
F. Kawamoto, H. Miyake, O. Kaneko, M. Kimura, N. T. Dung, N. T. Dung, L. D. Dao, S. Isomura, Y. Wataya: Sequence variation in the 18S rRNA gene, a target for PCR-based malaria diagnosis, in Plasmodium ovale from Southern Vietnam. J. Clin. Microbiol., 34: 2287-2289, 1996
C. Wongsrichanalai, N. T. Dung, T. Wimonwattrawatee, P. Sookto, G. Heppner, F. Kawamoto: In vitro susceptibility of Plasmodium falciparum isolates derivatives and other anti-malarials. Acta Tropica, 63: 151-158, 1997
O. Kaneko, M. Kimura, F. Kawamoto, M.U. Ferreria, K. Tanabe: Plasmodium falciparum: Allelic variation in the merozoite surface protein 1 gene in wild isolates from southern Vietnam. Exp. Parasitol., 86: 45-57, 1997
M. Kimura, O. Kaneko, Q. Liu, Y. Yamaguchi, K. Tanabe, Y. Wataya, M. Zhou, F. Kawamoto, S. Otani: Identification of the four species of human malaria parasites by nested PCR that targets sequences in the small variant subunit rRNA gene. Parasitol. Int., 46: 91-95, 1997
Q. Liu, S. Zhu, S. Mizuno, M. Kimura, P. Liu, S. Isomura, X. Wang, F. Kawamoto: Sequence variation in small subunit ribosomal RNA gene of Plasmodium malariae and its local prevalence in Sichuan, China. J. Clin. Microbiol., 36: 3378-3381, 1998
M.U. Ferreira, Q. Liu, M. Kimura, B. T. Ndawi, K. Tanabe, F. Kawamoto: Allelic diversity in the merozoite surface protein-1 and epidemiology of multiple clone Plasmodium falciparum infections in northern Tanzania. J. Parasitol., 84: 1286-1289, 1998
M.U. Ferreira, Q. Liu, M. Zhou, M. Kimura, O. Kaneko, H.V. Thien, S. Isomura, K. Tanabe, F. Kawamoto: Stable pattern of allelic diversity at the merozoite surface protein-1 locus of Plasmodium falciparum in clinical isolates from Southern Vietnam. J. Eukaryotic. Microbiol., 45: 131-136, 1998
M.U. Ferreira, Q. Liu, O. Kaneko, M. Kimura, K. Tabnabe, E.A.S. Kimura, A.M. Kazin, F. Kawamoto: Allelic diversity at the merozoite surface protein-1 locus of Plasmodium falciparum in clinical isolates from southwestern Brazilian Amazon. Am. J. Trop. Med. Hyg., 57: 474-480, 1998
M.U. Ferreira, O. Kaneko, M. Kimura, Q.Liu, F. Kawamoto, K. Tanabe: Allelic diversity at the merozoite surface protein-1 (MSP-1) locus in natural Plasmodium falciparum populations: A brief overview. Mem. Inst. Oswald Cruz, 93: 631-638, 1998
M. Zhou, Q. Liu, W. Panart, S. Prajakwong, A. Pensiri, M. Kimura, H. Matsuoka, M.U. Ferreira, C. Wongsrichanalai, S. Isomura, F. Kawamoto: High prevalence of Plasmodium malariae and Plasmodium ovale in malaria patients along the Thai-Myanmar Border, as revealed by acridine orange staining and PCR-based diagnoses. Trop. Med. Int. Health, 3: 304-312, 1998
I.S. Tantular, S. Iwai, K. Lin, S. Basuki, T. Horie, H.H. Htay, H. Matsuoka, H. Marwoto, C. Wongsrichanalai, Y.P. Dachlan, S. Kojima, A. Ishii, F. Kawamoto: Field trials of a rapid test for G6PD deficiency in combination with a rapid diagnosis of malaria. Trop. Med. Int. Health, 4: 245-250, 1999
L.A. Da Silveria, M. Dorta, E.A.S. Kimura, A.M. Katzin, F. Kawamoto, K. Tanabe, M.U. Ferreira: Allelic diversity and antibody recognition of Plasmodium falciparum merozoite Surface protein 1 during hypoendemic malaria transmission in the Brazilian Amazon region. Infection & Immunity, 67: 5906-5916, 1999
I.S. Tantular, S. Pusarawati, B. Wirjatmadi, H. Marwoto, Y.P. Dachlan, M. Kimura, F. Kawamoto: Field survey of malaria at the Flores Island, East Nusa Tenggara Province, Indonesia, and detection of Plasmodium malariae and P. ovale using two PCR-based diagnoses. Folia Med. Indonesia, 35: 38-42, 1999
M.T.V. Cavasini, W.L. Riberio, F. Kawamoto, M.U. Ferrira: How prevalent is Plasmodium malariae in Western Brazilian Amazon? Rev. Soc. Bra. Med. Trop., 33: 489-492, 2000
M. Adachi, K. Manji, R. Ichimori, H. Nishimori, K. Shindo, N. Matsubayashi, R. Mbise, M. Massawe, Q. Liu, F. Kawamoto, Y. Chinzei, M. Sakurai: Detection of congenital malaria by polymerase-chain- reaction methodology in Dares Salaam, Tanzania. Parasitol. Res., 86: 615-8, 2000
Q. Liu, M.U. Ferreira, B.T. Ndawi, H. Ohmae, I.S. Adagu, T. Morikawa, T. Horii, S. Isomura, F. Kawamoto: Sequence diversity of serine repeat antigen gene exon II of Plasmodium falciparum in worldwide collected wild isolates. Southeast A. J. Trop. Med. Pub. Health, 31: 808-817, 2000
E.H.E. Hoffmann, L.A. Da Silveria, R. Tonhosolo, F.J.T. Pereira, W.L. Riberio, A.P. Tonon, F. Kawamoto, M.U. Ferreira: Geographical patterns of allelic diversity in the Plasmodium falciparum malaria- vaccine candidate, merozoite surface protein-2. Ann. Trop. Med. Parasitol., 95:117-132, 2001
D.P. Mason, C. Wongsrichanalai, K. Lin, R.S. Miller, F. Kawamoto: The panmalarial antigen detected by the ICT Malaria P.f/P.v.immunochromatographic test is expressed by Plasmodium malariae. J. Clin. Microbiol. 39: 2035, 2001
A. Laoboonchai, F. Kawamoto, N. Thanusingha, S. Kojima, R.S. Millar, K.C. Kain, C. Wongsrichanalai: PCR-based ELISA technique for malaria diagnosis of specimens from Thailand. Trop. Med. Int. Health, 6: 458-462, 2001
C. Wongsrichanalai, K. Lin, L.W. Pang, M.A. Faiz, H. Noedl, T. Wimonwattrawatee, A. Laoboonchai, F. Kawamoto: In vitro susceptibility of Plasmodium falciparum isolates from Myanmar to antimalarial drugs. Am. J. Trop. Med. Hyg., 65: 450-455, 2001
K. Iwai, A. Hirono, M. Matsuoka, F. Kawamoto, T. Horie, K. Lin, I. S. Tantular, Y. P. Dachlan, H. Notopuro, I. Noor, E.A.S.A. Manan, H. Fujii, S. Miwa, A. Ishii: Distribution of glucose- 6- phosphate dehydrogenase mutations in Southeast Asia. Human Genetics, 108: 445-449, 2001
T. T. Win, I.S. Tantular, S. Pusarawati, H. Kerong, K. Lin, H. Matsuoka, A. Ishii, F. Kawamoto: Detection of Plasmodium ovale by the ICT Malaria P.f/P.v.immunochromatographic test. Acta Tropica, 80: 283-284, 2001
D. P. Mason, F. Kawamoto, K. Lin, A. Laoboonchai, C. Wongsrichanalai: A comparison of two rapid field immunochromatographic tests to expert microscopy in the diagnosis of malaria. Acta Tropica, 82: 51-59, 2002
T.T. Win, K. Lin, S. Mizuno, M. Zhou, Q. Liu, M.U. Ferreira, I.S. Tantular, S., Kojima, A. Ishii, F. Kawamoto: Wide distribution of Plasmodium ovale in Myanmar. Trop. Med. Int. Health 7: 231-239, 2002
F. Kawamoto, T.T. Win, S. Mizuno, K. Lin, O. Kyaw, I.S. Tantular, D.P. Mason, M. Kimura, C. Wongsrichanalai: Unusual Plasmodium malariae-like parasites in Southeast Asia. J. Parasitol., 88: 350-357, 2002
特許出願：川本文彦 四日熱マラリア原虫とその診断、出願番号 特願2002-055915, 2002
M. U. Ferreira, S. Nair, T.V. Hyunh, F. Kawamoto, T.J.C. Anderson: Microsatellite characterization of Plasmodium falciparum from cerebral and uncomplicated malaria patients in Southern Vietnam. J. Clin. Microbiol. 40: 1854-1857, 2002
M. U. Ferreira, W.L. Riberio, A.P. Tonon, F. Kawamoto, S.M. Rich: Sequence diversity and evolution of the malaria vaccine candidate merozoite surface protein-1 (MSP-1) of Plasmodium falciparum. Gene, 304: 301-309, 2003
I. Safitri, A. Jalloh, I.S. Tantular, S. Pusarawati, T.T. Win, Q. Liu, M.U. Ferreira, Y.P. Dachlan, T. Horii, F. Kawamoto: Sequence diversity in the amino-terminal region of the malaria- vaccine candidate serine repeat antigen (SERA) in natural Plasmodium falciparum populations. Parasitol. Int., 52: 117-131, 2003
I.S. Tantular, A. Jalloh, S. Pusarawati, Y. Azuno, K. Lin, H. Kerong, Y.P. Dachlan, A. Ishii, F. Kawamoto: Synergistic enhancement of a copper chelator, bathocuproine disulphonate, and cysteine on in vitro growth of Plasmodium falciparum in glucose-6-phosphate dehydrogenase- deficient erythrocytes. S. A. J. Trop. Med. Pub. Health, 34: 301-309, 2003
I.S. Tantular, F. Kawamoto: An improved, simple screening method for detection of glucose-6- phosphate dehydrogenase deficiency. Trop. Med. Int. Health, 8:569-574, 2003
特許出願：川本文彦 グルコース-６-リン酸脱水素酵素異常症の保因の診断方法、出願番号 特願2003-071219, 2003
K. Iwai, H. Matsuoka, F. Kawamoto, M. Arai, S. Yoshida, M. Hirai, A. Ishii: A rapid single-step screening method for glucose-6-dehydrogenase deficiency in field applications. Jpn. J. Trop. Med. Hyg., 31: 93-97, 2003
A.L. Pickard, C. Wongsrichanalai, A. Purfield, D. Kamwendo, K. Emery, C. Zalewski, F. Kawamoto, R.S. Miller, S.R. Meshnick: Resistance to anitmalarials in Southeast Asia and genetic polymorphisms in pfmdr1. Antimicrob Agents Chemother., 47: 2418-2423, 2003
H. Matsuoka, M. Arai, S. Yoshida, I.S. Tantular, S. Pusarawati, H. Kerong, F. Kawamoto: Five different glucose-6-phophate dehydrogenase (G6PD) variants found among 11 G6PD-deficient persons in Flores Island, Indonesia. J. Human Genet., 48: 541-544, 2003
T.T. Win, A. Jalloh, I.S. Tantular, T. Tsuboi, M.U. Ferreira, F. Kawamoto: Molecular analysis of Plasmodium ovale variants. Emerg. Inf. Dis., 10: 1235-1240, 2004
A. Jalloh, I.S. Tantular, S. Pusarawati, A.P. Kawilarang, H. Kerong, K. Lin, M.U. Ferreira, H. Arai, K. Kita, F. Kawamoto: Rapid epidemiologic assessment of glucose-6-phosphate dehydrogenase deficiency in malaria-endemic areas in Southeast Asia using a novel diagnostic kit. Trop. Med. Int. Health, 9: 615-623, 2004
H. Matsuoka, J. Wang, H. Hirai, M. Arai, S. Yoshida, T. Kobayashi, A. Jalloh, K. Lin, F. Kawamoto: Glucose-6-phosphate dehydrogenase (G6PD) mutations in Myanmar: G6PD Mahidol (487G>A) is the most common variant in the Myanmar population. J. Human Genet., 49: 544-547, 2004
＜総説＞
F. Kawamoto, P.F. Billingsley: Rapid diagnosis of malaria by fluorescence microscopy. Parasitol. Today, 8: 69-71, 1992
川本文彦: マラリア原虫の生殖体形成機構。化学療法の領域、8: 504-511、1992
川本文彦: かゆい毛虫・痛い毛虫。動物たちの地球、78: 187、1992
川本文彦: ガの毒､毛虫の毒。現代化学、282: 32-36、1994
川本文彦: 簡易蛍光観察法によるマラリア迅速診断と新しいハロゲン光源装置について。 熱帯、27: 105-115、1994
川本文彦､劉 慶、水野サホ子、木村政継､下野國夫､井関基弘: アクリジンオレンジ染色に よるマラリアの迅速診断法。臨床検査、42: 243-247、1998
川本文彦、水野サホ子: マラリア原虫を見落とすな―アクリジンオレンジ染色。 臨床検査、43、1625-1629、1999
F. Kawamoto, Q.Liu, M.U. Ferreira, I.S. Tantular: How prevalent are Plasmodium ovale and P. malariae in East Asia ? Parasitol. Today, 15: 422-426, 1999
川本文彦: この疾患はどう変わってきたか「マラリア」。現代医学、48: 381-386、2000
F. Kawamoto: Rapid biological tests applicable to malaria control in rural areas. Mekong Malaria Forum, 6: 84-89, 2000
F. Kawamoto: Sequence variations in the SSUrRNA genes in P. ovale and P. malariae. Mekong Malaria Forum, 6: 95-97, 2000
＜これまでの著書（分担執筆）＞
川本文彦、滝野長平: 鱗翅目。現代皮膚科学大系、動物性皮膚症・体内寄生性皮膚症、 中山書店、8巻、pp. 246-259、1984
F. Kawamoto, N. Kumada: Biology and venoms of Lepidoptera. In: Handbook of Natural Toxins, Vol. 2, (ed., A. Tu), Marcel Dekker, pp. 291-330, 1984
川本文彦: 原虫学：原虫と原虫感染症。医系微生物学（加藤延夫編）、朝倉書店、pp. 307-316、 1984
川本文彦: ソロモン諸島における簡易蛍光観察法によるマラリア迅速診断の試み。 ソロモン諸島とマラリア（石井明編）、日本熱帯医学協会、pp. 30-35、1995
F. Kawamoto: Rapid diagnosis of malaria using a simple fluorescence microscopic system in the Solomon islands. In: Malaria Research in the Solomon islands (ed., A. ishii), Inter Group Co., Tokyo, pp.28-32, 1998
川本 文彦: アクリジンオレンジ(AO)染色。マラリア学ラボマニュアル（北 潔編）、菜根出版 pp.27-30, 2000
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