Emeritusprofessor
Visiting professor
�F Yasunori HIGUCHI
Research Projects�FAnalysis of osteopontin (OPN) function.
OPN is a phosphoglycoprotein secreted by osteoblasts mainly and has many functions. We are analyzing the relationship of OPN functions and active domains in vitro, especially related to osteporosis.
Hobby �FVegetable cultivation, Tramping over the hills

1)Nakamura, K., Tsukamoto, Y., Hijiya, N., Higuchi, Y., Yano, S., Yokoyama, S., Kumamoto T., Moriyama M.: Induction of GNE in myofibers after muscle injury. Pathobiol. 77: 191-199, 2010
2)Matsuno, O., Ono, E., Ueno, T.,Takenaka, R., Nishitake, T., Hiroshige, S.,Miyazaki, E., Kumamoto, T.,Higuchi Y.: Increased serum ADAM8 concentration in patientswith drug-induced eosinophilic pneumonia-ADAM8expression depends on the allergen route of entry. Resp. Med. 104: 34-39, 2010
3)Eshima, N., Iwata, O., Iwata, S.,Tabata, M., Higuchi, Y.,Matsuishi, T.,Karukaya, S.: Age and gender specific prevalence of HTLV-1. J. Clin. Virol. 45: 135-138, 2009
4)Ishii, S., Chang, H.-H., Yoshioka, H., Shimada, T.,Mannen, K.,Higuchi, Y., Taguchi, A., Fan, J.-Q.: Preclinical efficacy and safety of 1-deoxygalactonojirimycin in mice for Fabry disease. J. Pharamacol. Exp. Ther.  328: 723-731, 2009
5)Matsuno, O., Kumamoto, T., Higuchi, Y.: ADAM8 in Allergy. Inflamma. AllergyDrug Targets 7: 108-112, 2008
6)Matsuno, O., Miyazaki, E., Nureki, S., Ueno, T., Ando, M., Ito, K., Kumamoto, T., Higuchi, Y.: Elevated soluble ADAM8 in BALF in patients with eosinophilic pneumonia. Int. Arch. Aller. Immunol. 142(4):285-290, 2007