Emeritusprofessor
Visiting professor
F Yasunori HIGUCHI
Research ProjectsFAnalysis of osteopontin (OPN) function.
OPN is a phosphoglycoprotein secreted by osteoblasts mainly and has many functions. We are analyzing the relationship of OPN functions and active domains in vitro, especially related to osteporosis.
Hobby FVegetable cultivation, Tramping over the hills

1)Nakamura, K., Tsukamoto, Y., Hijiya, N., Higuchi, Y., Yano, S., Yokoyama, S., Kumamoto T., Moriyama M.: Induction of GNE in myofibers after muscle injury. Pathobiol. 77: 191-199, 2010
2)Matsuno, O., Ono, E., Ueno, T.,Takenaka, R., Nishitake, T., Hiroshige, S.,Miyazaki, E., Kumamoto, T.,Higuchi Y.: Increased serum ADAM8 concentration in patientswith drug-induced eosinophilic pneumonia-ADAM8expression depends on the allergen route of entry. Resp. Med. 104: 34-39, 2010
3)Eshima, N., Iwata, O., Iwata, S.,Tabata, M., Higuchi, Y.,Matsuishi, T.,Karukaya, S.: Age and gender specific prevalence of HTLV-1. J. Clin. Virol. 45: 135-138, 2009
4)Ishii, S., Chang, H.-H., Yoshioka, H., Shimada, T.,Mannen, K.,Higuchi, Y., Taguchi, A., Fan, J.-Q.: Preclinical efficacy and safety of 1-deoxygalactonojirimycin in mice for Fabry disease. J. Pharamacol. Exp. Ther.  328: 723-731, 2009
5)Matsuno, O., Kumamoto, T., Higuchi, Y.: ADAM8 in Allergy. Inflamma. AllergyDrug Targets 7: 108-112, 2008
6)Matsuno, O., Miyazaki, E., Nureki, S., Ueno, T., Ando, M., Ito, K., Kumamoto, T., Higuchi, Y.: Elevated soluble ADAM8 in BALF in patients with eosinophilic pneumonia. Int. Arch. Aller. Immunol. 142(4):285-290, 2007