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| EmeritusProfessor Visiting Professor |
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Tatsuo Shimada PhD |
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| Research Projects | ： | (1) Structure and Function of the Cardiac Conduction System
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has been well-known that the heart rhythm is controlled by the cardiac
conductionsystem. So far, we have studied the cytoarchitecture and
ultrastrucute of the myocardium and the conduction system using
immuno-histochemical and electron microscopic techniques. In mammalian
hearts, individual working cardiac myocytes weresurroundedby the
thin sheathconsisting of reticular fibrils of 40nm in
diameter, while the Purkinje cell strands were concealed by the thick
reticular fiber sheath. Connective tissue elements of the cardiac
conduction system in various experimental conditions are investigated. | | | | | | （2） Structure and Function of the Extravascular Fluid Pathway | | | The
extravascular fluid pathway is widely distributed throughout the
tissues or organs alongside blood and lymphatic vessels, and spreads
throughout the connective tissue as a reticular formation containing
argyrophil fibers(reticular fibers). Tissue fluid and corpuscular
substances constantly flow in a specific direction in this pathway. We
have reconfirmed the presence of theextravasucular fluid pathway in the diaphragmatic peritoneum and the pleura. | | | | | | (3) Praise of Dr. SunaoTawara | | | A
NPO Corporation,a club of TawaraSunao has praised his
achievements.Tawara discovered the cardiac conduction
system.TheTawara-Aschoff Meeting on the Cardiac Conduction System has
exhibited in Japan and Germany every two years. | | | |
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| |  | | | | 1) | Kusunoki
M, Misumi J, Shimada T, Aoki K, Matsuo N, Sumiyoshi H, Yamaguchi T,
Yoshioka H. Long-term administration of the fungus toxin,
sterigmatocystin,induces intestinal metaplasia and increases the
proliferative activity of PCNA, p53, and MDM2 in the gastric mucosa of
aged Mongolian gerbils. Environ Health Prev Med. 16(4): 224-231, 2011 |  | | | | | 2) | Akashi
Y, Noguchi T, Nagai K, Kawahara K, Shimada T. Cytoarchitecture of the
lamina muscularis mucosae and distribution of the lymphatic vessels in
the human stomach. Med Mol Morphol. 44(1): 39-45, 2011 | | | | | | 3) | Kato
A, Okamoto O, Ishikawa K, Sumiyoshi H, Matsuo N, Yoshioka H, Nomizu
M, Shimada T, Fujiwara S. Dermatopontin interacts with
fibronectin, promotes fibronectin fibril formation, and enhances cell
adhesion. J Biol Chem. 29;286(17): 14861-14869, 2011 | | | | | | 4) | Ono
N, Yamaguchi T,Ishikawa H, Arakawa M, Saikawa T, Morphological variety
of the Purkinje fiber network in mammalian hearts, as revealed by light
and electron microscopy. Arch. Histol. Cytol 72(3):139-149, 2009 | | | | | | 5) | Okamoto
O, Ando T, Watanabe A, Sato F, Mimata H, Shimada T, Fujiwara S. A novel
point mutation in type III collagen gene resulting in exon 24 skipping
in acase of vascular type Ehlers-Danlos syndrome. Arch Dermatol Res.
300(9): 525-529, 2008 | | | | | | 6) | Wakisaka
O, Takahashi N, Shinohara T, Ooie T, Nakagawa M, Yonemochi H, Hara M,
Shimada T, Saikawa T, Yoshimatsu H. Hyperthermia treatment prevents
angiotensin II-mediated atrial fibrosis and fibrillation via induction
of heat-shock protein 72. J Mol Cell Cardiol. 43(5): 616-626, 2007 | | | | | | 7) | Shinohara
T, Takahashi N, Kohno H, Yamanaka K, Ooie T, Wakisaka O, Murozono Y,
Taniguchi Y, Torigoe Y, Hara M, Shimada T, Saikawa T, Yoshimatsu H.
Mitochondria are targets for geranylgeranylacetone-induced
cardioprotection against ischemia-reperfusion in the rat heart. Am J
Physiol Heart Circ Physiol. 293(3): H1892-1899, 2007 | | | | | | 8) | Kageyama
M, Nakatsuka K, Yamaguchi T, Owen RL, Shimada T. Ocular defense
mechanisms with special reference to the demonstration and functional
morphology of the conjunctiva-associated lymphoid tissue in Japanese
monkeys. Arch Histol Cytol. 69(5): 311-322, 2006 | | | | | | 9) | Ou
B, Nakagawa M, Kajimoto M, Nobe S, Ooie T, Ichinose M, Yonemochi H, Ono
N, Shimada T, Saikawa T. Heterogeneous expression of connexin 43 in the
myocardium of rabbit right ventricular outflow tract. Life Sci. 77(1):
52-59, 2005 | | | | | | 10) | Shimada
T, Kawazato H, Yasuda A, Ono N, Sueda K. Cytoarchitecture and
intercalated disks of the working myocardium and the conduction system
in the mammalian heart. Anat Rec A Discov Mol Cell Evol Biol. 280(2):
940-951, 2004 | |
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