Collaborator ： Atsumi Taguchi Research project ： Generation of mouse model for Fabry disease and its application for therapy 1) Taguchi T, Maruyama H, Nameta M, Yamamoto T, Matsuda J, Kulkarni A, Yoshioka H, and Ishii S: A symptomatic Fabry disease mouse model generated by inducing globotrialceramide synthesis. Biochem J 456, 373-383, 2013. 2) Shiozuka C, Taguchi A, Matsuda J, Noguchi Y, Kunieda T, Uchio-Yamada K, Yoshioka H, Hamanaka R, Yano S, Yokoyama S, Mannen K, Kulkarni AB, Furukawa K, Ishii S: Increased globotriaosylceramide levels in a transgenic mouse expressing human. J Biochem 149, 161-17-, 2011. 3) Ishii S, Chang H-H, Yoshioka H, Shimada T, Mannen K, Higuchi Y, Taguchi A, Fan J-Q : Preclinical efficacy and safety of 1-deoxygalactonojirimycin in mice for Fabry disease. J. Pharmacol. Exp. Ther. 328, 723-731, 2009.