Tipanan Khunsri (Tip)
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TIPANAN KHUNSRI 大分大学医学部感染予防医学講座 大学院生 |
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NATIONALITY:
Thailand 
RESEARCH PROJECT
| Investigating the Role of the CCR1–CCL9 Axis in Psoriatic Inflammation. Psoriasis is a chronic inflammatory skin disorder characterized by excessive keratinocyte proliferation and immune cell infiltration. The imiquimod (IMQ)-induced mouse model closely mimics human psoriasis and is widely used to study its immune mechanisms. Chemokines direct immune cell migration to inflamed tissues, but the roles of specific chemokine pathways are not fully understood. CCR1, a chemokine receptor that binds ligands such as CCL9, regulates myeloid and T cell recruitment during inflammation. While dysregulation of this pathway is linked to chronic inflammatory and autoimmune diseases, its role in psoriasis remains unclear. Clarifying the contribution of the CCR1–CCL9 axis to psoriatic inflammation may improve understanding of immune regulation in the skin. This project will examine the functions of CCR1 and CCL9 in IMQ-induced psoriatic inflammation using knockout mouse models. We will analyse inflammatory responses, immune cell infiltration, and cytokine expression to assess how disruption of this chemokine axis affects disease progression. These findings may identify CCR1–CCL9 signalling as a potential therapeutic target for psoriasis. |
SUPERVISOR
Prof. Kobayashi
EDUCATION and PROFESSIONAL EXPERIENCE
- October 2025 – present, Oita University Graduate School of Medicine
- 2022 – 2024, Master degree of Science (Medical Technology), Department of Clinical Microbiology and Applied Technology,
Faculty of Medical Technology, Mahidol University, Thailand
- 2018-2022, Bachelor degree of Science (Medical Technology), Faculty of Medical Technology, Prince of Songkhla University,
Thailand
Internship (Medical Technology Training) • Songkhlanakarin Hospital, Hatyai, Songkhla, Thailand Dec 2021 – Mar 2022
Research Assistant • Department of Clinical Microbiology and Applied Technology Feb 2025 – Sep 2025
PUBLICATIONS
- Khunsri T, Thawornpan P, Tianpothong P, Suangtamai T, Ngamjanyaporn P, Leepiyasakulchai C, Wangriatisak K, Pisitkun P, Chootong P. Activation of circulating TFH17 cells associated with activated naive and double negative 2 B cell expansion, and disease activity in systemic lupus erythematosus patients. Arthritis Res Ther. 2024 Sep 11;26(1):159. doi: 10.1186/s13075-024-03394-7. PMID: 39261963; PMCID: PMC11389436.
- Thawornpan P, Salsabila ZZ, Kochayoo P, Khunsri T, Malee C, Wangriatisak K, Leepiyasakulchai C, Ntumngia FB, Adams JH, Chootong P. Polarization toward Tfh2 cell involved in the development of MBC and antibody responses against Plasmodium vivax infection. PLoS Negl Trop Dis. 2024 Oct 30;18(10):e0012625. doi: 10.1371/journal.pntd.0012625. PMID: 39475899; PMCID: PMC11524495.
- Kagoshima Y, Sachi N, Kasahara Y, Yamamoto R, Ariki S, Soga Y, Ekronarongchai S, Umeki T, Khunsri T, Okamoto M, Kamiyama N, Murakami K, Mizukami K, Palaga T, Ozaka S, Kobayashi T. CCL9/CCR1 chemokine signaling plays a protective role in limiting intestinal inflammation by maintaining an anti-inflammatory M2 macrophage pool in the intestinal lamina propria. Biochem Biophys Res Commun. 2025 Oct 30; 786:152763. doi: 10.1016/j.bbrc.2025.152763. Epub 2025 Oct 6. PMID: 41066980.
Scientific Society
RESEARCH SKILLS
RESEARCH INTERESTS