研究室配属　Research Training

◆2024年の研究室配属

NEWS!　2024年5月7日からの研究室配属に先駆けて、タイの協定校であるマヒドン大学医学部から短期留学生３名が4月から約１ヶ月間の研究室配属を始めます。今年は園田さんと山本くんが早期研究学生として研究を開始しています。加えて、林くんも一般枠として配属します。また、今年は新たな試みとして、本学の学生がタイの協定校に短期留学します。これに参加するのは、椎名さん、武田さん、近森くんです。椎名さんと近森くんは当講座に、武田さんは分子病理に配属して短期留学を体験します。さらに、タイの協定校であるマッハサラカーム大学とチュラロンコン大学から、それぞれ３名と４名の学生を受け入れます。タイから来る留学生は、当講座の他に細胞生物学講座、神経生理学講座および分子病理学講座に配属する予定です。
配属学生　氏名 研究テーマ コメント

　2141049　園田　八重子		 ●　乾癬の病態におけるケモカインの機能解析
　　指導教員：小林、Ekronarongchai
　自己免疫疾患である乾癬の増悪因子として炎症性サイトカインIL-17が報告されている。IL-17を産生する細胞サブセットはいくつかあるが、それらの炎症局所への遊走には種々のケモカインが関与していると考えられる。CRISPR-Cas9システムを用いて樹立された様々なケモカイン遺伝子欠損マウスに実験的に乾癬様炎症を誘導しその病態を解析してケモカインの重要性を明らかにする。

技術：マウス乾癬モデル、PCR法、病理学的解析、免疫染色、フローサイトメトリー

【一言】
　
2141103　山本　玲		 ●　疾患モデル動物を用いた大腸炎に関する研究
　　指導教員：小林、鹿子嶋
　ケモカインおよびケモカイン受容体の遺伝子欠損マウスを用いて炎症性腸疾患の病態を解析する。これにより、潰瘍性大腸炎の新たな発症機序を明らかにし新規治療法の開発に資する。

技術：マウス腸炎モデル、PCR法、病理学的解析、免疫染色、フローサイトメトリー

【一言】
　2141072　林　由晃

●　CRISPR-Cas9システムを用いたトキソプラズマの新たな病原性分子の探索
　　指導教員：神山
　トキソプラズマ原虫が妊婦が初感染した場合、子供に重篤な症状が起きる場合がある。これは先天性トキソプラズマ症と呼ばれ、我が国での原因不明の流産などの原因となっているケースも少なくない。CRISPR-Cas9システムを用いて候補遺伝子を欠損したトキソプラズマ株を作製し、マウスへ感染させる。免疫学的手法による病態解析を実施し、トキソプラズマの病原性を規定する新規分子の探索を行う。

技術：CRISPR-Cas9、PCR法、マウス感染実験、病理学的解析、免疫染色

【一言】

　2141043　椎名　優里

●　タイ・マヒドン大学留学
　　指導教員：小林
　

技術：次世代シーケンサー、RNAseq

【一言】滝が好きです

　2141056　近森　優樹

●　自然免疫応答の訓練免疫　タイ・チュラロンコン大学留学
　　指導教員：小林, Prof. Tanapat Palaga
　

技術：

【一言】

Kamolnut Mahitthirogh
(Preem)
Faculty of Medicine Siriraj Hospital, Mahidol University		 【comments】
Preem: Beyond the research knowledge, Oita is a peaceful city surrounded by beautiful scenery such as cherry blossoms, a lot of mountain views, wonderful places like Yufuin and Beppu, nice weather, and cold temperatures. Not only the scenery but cuisines and fruits here are also very delicious. About restaurant, I really recommend Yotsuba and Yamanami because their foods are good and have reasonable prices that are very suitable for university students. Moreover, every sensei and senpai is very nice, friendly and always helps me to learn a lot of things that I never knew before. I really appreciate it and I will always cherish these friendships and memories from this one-month exchange program forever.
 【comments】

Phuripat Atthakorn
(Tutor)
Faculty of Medicine Siriraj Hospital, Mahidol University		 【comments】
I feel immensely honored to have the opportunity to study and observe here at this university, Oita University. Both the professors and senior students are very kind. They warmly welcome us. The university is situated amidst natural beauty, which makes the surroundings incredibly serene. Not only is the scenery beautiful, but the university buildings themselves are also stunning. The hospital, classrooms, and research buildings are all equally impressive. There is a plethora of research equipment available here, making it ideal for those interested in research work. Overall, I am very happy to have had the chance to study and observe here. I hope that those who read this will have the opportunity to experience the same wonderful experiences as me. Thank you.
【comments】

Pimnara Aimyen
(Rally)
Faculty of Medicine Siriraj Hospital, Mahidol University		 【comments】
Rally: During research practicing at Oita University's Department of Cell Biology, I had the opportunity to experience numerous wonderful things. It was an honor to have a chance to work with Hanada-sensei Shiraishi-sensei, Shimizu-sensei and other members in the lab. Their unwavering kindness, thoughtfulness, and assistance greatly contributed to my learning experience. Throughout my time there, I acquired invaluable knowledge, particularly in research techniques such as PCR ,Gell electrophoresis, Bacteria transformation pertinent to the field of cell biology, which I believe will greatly benefit my future career endeavors. Furthermore, The warmth and hospitality extended by both the university community and students there further enhanced my stay. Interactions with Oita students were particularly welcoming, as their generosity and support eased the transition into a new and unfamiliar environment. I am grateful to both the professors and students for their guidance and friendliness , which significantly contributed to my comfort and sense of reassurance during my time at Oita University. Moreover, Oita University boasts a serene ambiance, complemented by the beauty of its surroundings. Beyond Oita, the other cities on Kyushu Island have left an memorable impression on me. My favorite spot is Yufuin standing out for its charm and captivating array of shops. In the future if i have a chance , i am definitely going to revisit here again.
 【comments】

CHUSAAD PHETKAEOSUK
(Kanploo)
Faculty of Vetarinaly Science, Mahasarakham University		 (to be determined)
 【comments】

WATTHANAPORN JANCHA|
(Sea)
Faculty of Vetarinaly Science, Mahasarakham University		 (to be determined)
 【comments】

WILASINEE BOONPOO

Faculty of Vetarinaly Science, Mahasarakham University		 (to be determined)
 【comments】

Nathatai Sornplang
(Pim)
Faculty of Science, Chulalongkorn University		 (to be determined)
 【comments】

Pacharaporn Ketkeaw
(Ploy)
Faculty of Science, Chulalongkorn University		 (to be determined)
 【comments】

Ploychomphuj Jinda
Faculty of Science, Chulalongkorn University		 (to be determined)
 【comments】

Pran Panyakong
Faculty of Science, Chulalongkorn University		 (to be determined)
 【comments】

Tutor-kun Preem-san and Rally-san, second year medical students at Siriraj Hospital, Mahidol University, Thailand, joined us on April 1st. They participate in our program of research training. Tutor-kun studys on autoimmune diseases using mouse models with Nan-san in our lab. Preem-san joined R.Hanada's Lab and Rally-san joined T. Hanada's lab.

April 3rd: Tutor, Preem and Rally made a courtesy call on the Dean of the Faculty of Medicine, Prof. Inomata.

Students from the Faculty of Medicine of Mahidol University interact with students from the Faculty of Medicine of Oita University. They meet every evening to discuss various topics.

On Sunday, April 7th, Yuri Shiina guided students from the Faculty of Medicine of Mahidol University to Yufuin.

We saw water fall, Ryushonotaki, in Shonai town. We then visited Yufuin town where we saw the Kinrinko lake and visited the Tenso shrine. We went shopping on the Yunotsubo-kaido street.



On April 9, Dr. Uchida presented his data research on H. pylori in Thailand for Thai students.

April 11: They visited the Department of Emergency and Critical Care Medicine, where they were briefed by Dr. Kurosawa on how to operate the Doc Helicopter.
On April 15th, Tutor, Preem and Rally paid a courtesy call to the president of Oita University, Dr. Seigo Kitano.
President Kitano briefed the students on his work in Thailand as an endoscopic surgeon.
Let's have a SUSHIRO party!!!!
　　　　on April 15th
We had a GYOZA party on April 19th
April 26: Data Presentation. Mr. Tutor, Ms. Preem and Ms. Rally presented their data to their mentors and colleagues.
Congratulations! They have completed the program.They were awarded the Study Abroad Encouragement Award by the Oita University Faculty of Medicine International Exchange Committee, and the award ceremony was held on after data presentation. The award was presented by the chair, Prof. Reiko Hanada. This award is given to students from partner universities who participate in research training at Oita University.