小林　隆志　Takashi Kobayashi (Ph.D.)

小林　隆志　Takashi Kobayashi (Ph.D.)

大分大学医学部感染予防医学講座　教授

PUBLICATIONS (T.K.)
Original Papers
  1. Chalalai T, Kamiyama N, Saechue B, Sachi N, Ozaka S, Ariki S, Dewayani A, Soga Y, Kagoshima Y, Ekronarongchai S, Okumura R, Kayama H, Takeda K, Kobayashi . TRAF6 signaling in dendritic cells plays protective role against infectious colitis by limiting C. rodentium infection through the induction of Th1 and Th17 responses. Biochem Biophys Res Commun.(2023) Aug 20;669:103-112.  doi: 10.1016/j.bbrc.2023.05.059.
  2. Hashizaki E, Sasai M, Okuzaki D, Nishi T, Kobayashi T, Iwanaga S, Yamamoto M. Toxoplasma IWS1 Determines Fitness in Interferon-γ-Activated Host Cells and Mice by Indirectly Regulating ROP18 mRNA Expression. mBio. (2023). Feb 28;14(1):e0325622. doi: 10.1128/mbio.03256-22. Epub 2023 Jan 30. PMID: 36715543.
  3. Ariki S, Ozaka S, Sachi N, Chalalai T, Soga Y, Fukuda C, Kagoshima Y, Ekronarongchai S, Mizukami K, Kamiyama N, Murakami K, Kobayashi T. GM-CSF-producing CCR2+ CCR6+ Th17 cells are pathogenic in dextran sodium sulfate-induced colitis model in mice. Genes Cells. (2023). Apr;28(4):267-276. doi: 10.1111/gtc.13008. Epub 2023 Jan 24.
  4. Sachi N, Kamiyama N, Saechue B, Ozaka S, Dewayani A, Ariki S, Chalalai T, Soga Y, Fukuda C, Kagoshima Y, Ekronarongchai S, Kobayashi T. CCL20/CCR6 chemokine signaling is not essential for pathogenesis in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis. Biochem Biophys Res Commun. (2023). Jan 22;641:123-131. doi: 10.1016/j.bbrc.2022.11.088. Epub 2022 Nov 30.
  5. Amada K, Hijiya N, Ikarimoto S, Yanagihara K, Hanada T, Hidano S, Kurogi S, Tsukamoto Y, Nakada C, Kinoshita K, Hirashita Y, Uchida T, Shin T, Yada K, Hirashita T, Kobayashi T, Murakami K, Inomata M, Shirao K, Aoki M, Takekawa M, Moriyama M. Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor. Cancer Sci. (2023). May;114(5):2189-2202. doi: 10.1111/cas.15735. Epub 2023 Feb 9.
  6. Takada I, Hidano S, Takahashi S, Yanaka K, Ogawa H, Tsuchiya M, Yokoyama A, Sato S, Ochi H, Nakagawa T, Kobayashi T, Nakagawa S, Makishima M. Transcriptional coregulator Ess2 controls survival of post-thymic CD4+ T cells through the Myc and IL-7 signaling pathways. J Biol Chem. (2022). Sep;298(9):102342. doi: 10.1016/j.jbc.2022.102342. Epub 2022 Aug 3. PMID: 35933014.
  7. Ozaki T, Kamiyama N, Saechue B, Soga Y, Gotoh R, Nakayama T, Fukuda C, Dewayani A, Chalalai T, Ariki S, Ozaka S, Sonoda A, Hirose H, Gendo Y, Noguchi K, Sachi N, Hidano S, Maeshima K, Gotoh K, Masaki T, Ishii K, Osada Y, Shibata H, Kobayashi T. Comprehensive lipidomics of lupus-prone mice using LC-MS/MS identifies the reduction of palmitoylethanolamide that suppresses TLR9-mediated inflammation. Genes Cells. (2022). Jul;27(7):493-504. doi: 10.1111/gtc.12944. Epub 2022 May 11.
  8. Dewayani A, Kamiyama N, Sachi N, Ozaka S, Saechue B, Ariki S, Goto M, Chalalai T, Soga Y, Fukuda C, Kagoshima Y, Maekawa Y, Kobayashi T. TRAF6 signaling pathway in T cells regulates anti-tumor immunity through the activation of tumor specific Th9 cells and CTLs. Biochem Biophys Res Commun. (2022) Jul 12;613:26-33. doi: 10.1016/j.bbrc.2022.04.125. Epub 2022 Apr 29.
  9. Ozaka S, Sonoda A, Ariki S, Minata M, Kamiyama N, Hidano S, Sachi N, Ito K, Kudo Y, Dewayani A, Chalalai T, Ozaki T, Soga Y, Fukuda C, Mizukami K, Ishizawa S, Nishiyama M, Fujitsuka N, Mogami S, Kubota K, Murakami K, Kobayashi T. Saireito, a Japanese herbal medicine, alleviates leaky gut associated with antibiotic-induced dysbiosis in mice. PLoS One. 2022 Jun 15;17(6):e0269698. doi: 10.1371/journal.pone.0269698. eCollection 2022.
  10. Ozaka S., Sonoda A., Ariki S., Kamiyama N., Hidano S., Sachi N., Ito K., Kudo Y., Minata M., Saechue B., Dewayani A., Chalalai T., Soga Y., Takahashi Y., Fukuda C., Mizukami K., Okumura R., Kayama H., Murakami K., Takeda K., Kobayashi T. Protease inhibitory activity of secretory leukocyte protease inhibitor ameliorates murine experimental colitis by protecting the intestinal epithelial barrier. Genes Cells. (2021).Oct;26(10):807-822. doi: 10.1111/gtc.12888.
  11. Hidano S, Mizukami K, Yahiro T, Shirakami K, Ito H, Ozaka S, Ariki S, Saechue B, Dewayani A, Chalalai T, Soga Y, Goto M, Sonoda A, Ozaki T, Sachi N, Kamiyama N, Nishizono A, Murakami K, Kobayashi T. Analysis of the Prevalence and Species of Anisakis nematode in Sekisaba, Scomber japonicus Caught in Coastal Waters off Saganoseki, Oita in Japan. Jpn J Infect Dis. (2021).Sep 22;74(5):387-391. doi: 10.7883/yoken.JJID.2020.859.
  12. Kurogi S, Hijiya N, Hidano S, Sato S, Uchida T, Tsukamoto Y, Nakada C, Yada K, Hirashita T, Inomata M, Murakami K, Takahashi N, Kobayashi T, Moriyama M. Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential. Pathobiology. (2021). 88(5):374-382.doi: 10.1159/000514593.
  13. Morisaki I, Shiraishi H, Fujinami H, Shimizu N, Hikida T, Arai Y, Kobayashi T, Hanada R, Penninger JM, Fujiki M, Hanada T. Modeling a human CLP1 mutation in mouse identifies an accumulation of tyrosine pre-tRNA fragments causing pontocerebellar hypoplasia type 10. Biochem Biophys Res Commun. (2021).Sep 17;570:60-66. doi: 10.1016/j.bbrc.2021.07.036.
  14. Saechue B, Kamiyama N, Wang Y, Fukuda C, Watanabe K, Soga Y, Goto M, Dewayani A, Ariki S, Hirose H, Ozaka S, Sachi N, Hidano S, Faisal K, Chowdhury R, Khan MAA, Hossain F, Ghosh P, Shirin T, Mondal D, Murakami K, Kobayashi T. Development of a portable reverse transcription loop-mediated isothermal amplification system to detect the E1 region of Chikungunya virus in a cost-effective manner. Genes Cells. (2020).Sep;25(9):615-625. doi: 10.1111/gtc.12797.
  15. Ratsada P, Hijiya N, Hidano S, Tsukamoto Y, Nakada C, Uchida T, Kobayashi T, Moriyama M. DUSP4 is involved in the enhanced proliferation and survival of DUSP4-overexpressing cancer cells. Biochem Biophys Res Commun. 528(3):586-593. (2020) doi: 10.1016/j.bbrc.2020.05.140.
  16. Runtuwene LR, Kawashima S, Pijoh VD, Tuda JSB, Hayashida K, Yamagishi J, Sugimoto C, Nishiyama S, Sasaki M, Orba Y, Sawa H, Takasaki T, James AA, Kobayashi T, Eshita Y. The Lethal(2)-Essential-for-Life [L(2)EFL] Gene Family Modulates Dengue Virus Infection in Aedes aegypti. Int J Mol Sci. (2020) Oct 12;21(20):7520. doi: 10.3390/ijms21207520.
  17. Tada K, Ohta M, Hidano S, Watanabe K, Hirashita T, Oshima Y, Fujnaga A, Nakanuma H, Masuda T, Endo Y, Takeuchi Y, Iwashita Y, Kobayashi T, Inomata M. Fucosyltransferase 8 plays a crucial role in the invasion and metastasis of pancreatic ductal adenocarcinoma. Surgery Today. 50(7):767-777(2020).
  18. Fujinami H, Shiraishi H, Hada K, Inoue M, Morisaki I, Higa R, Shin T, Kobayashi T, Hanada R, Penninger JM, Mimata H, Hanada T. CLP1 acts as the main RNA kinase in mice. Biochem Biophys Res Commun. 525:129-134 (2020).
  19. Matsuda-Hirose H, Yamate T, Goto M, Katoh A, Kouji H, Yamamoto Y, Sakai T, Uemura N, Kobayashi T, Hatano Y. Selective Inhibition of β-Catenin/Co-Activator Cyclic AMP Response Element-Binding Protein-Dependent Signaling Prevents the Emergence of Hapten-Induced Atopic Dermatitis-Like Dermatitis. Ann Dermatol. 31(6):631-639 (2019)
  20. Matsumoto R, Dainichi T, Tsuchiya S, Nomura T, Kitoh A, Hayden MS, Ishii KJ, Tanaka M, Honda T, Egawa G, Otsuka A, Nakajima S, Sakurai K, Nakano Y, Kobayashi T, Sugimoto Y, Kabashima K. Epithelial TRAF6 drives IL-17-mediated psoriatic inflammation. JCI Insight. 3(15):e121175 (2018).
  21. Kanaya T, Sakakibara S, Jinnohara T, Hachisuka M, Tachibana N, Hidano S, Kobayashi T, Kimura S, Iwanaga T, Nakagawa T, Katsuno T, Kato N, Akiyama T, Sato T, Williams IR, Ohno H. Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling. J Exp Med. 215(2) 501-519 (2018).
  22. Takada I, Tsuchiya M, Yanaka K, Hidano S, Takahashi S, Kobayashi T, Ogawa, H, Nakagawa S, Makishima M. Ess2 bridges transcriptional regulators and spliceosomal complexes via distinct interacting domains. Biochem Biophys Res Commun. 497(2):597-604 (2018).
  23. Saga K, Iwashita Y, Hidano S, Aso Y, Isaka K, Kido Y, Tada K, Takayama H, Masuda T, Hirashita T, Endo Y, Ohta M, Kobayashi T, Inomata M. Secondary Unconjugated Bile Acids Induce Hepatic Stellate Cell Activation. Int J Mol Sci. 19(10). pii:E3043. (2018).
  24. Noguchi K, Kamiyama N, Hidano S, Gendo Y, Sonoda A, Ozaki T, Hirose H, Sachi N, Saechue B, Ozaka S, Eshita Y, Mizukami K, Kawano K, Kobayashi T. Autoimmune sialadenitis is associated with the upregulation of chemokine/chemokine receptor pairs in T cell-specific TRAF6-deficient mice. Biochem Biophys Res Commun. 504(1) 245-250 (2018).
  25. Ji RC, Eshita Y, Kobayashi T, Hidano S, Kamiyama N, Onishi Y. Role of simvastatin in tumor lymphangiogenesis and lymph node metastasis. Clin Exp Metastasis 35(8) 785-796 (2018).
  26. Sonoda A, Kamiyama N, Ozaka S, Gendo Y, Ozaki T, Hirose H, Noguchi K, Saechue B, Sachi N, Sakai K, Mizukami K, Hidano S, Murakami K, Kobayashi T. Oral administration of antibiotics results in fecal occult bleeding due to metabolic disorders and defective proliferation of the gut epithelial cell in mice. Genes Cells 23(12) 1043-1055 (2018).
  27. Gendo Y, Matsumoto T, Kamiyama N, Saechue B, Fukuda C, Dewayani A, Hidano S, Noguchi K, Sonoda A, Ozaki T, Sachi N, Hirose H, Ozaka S, Eshita Y, Mizukami K, Okimoto T, Kodama M, Yoshimatsu T, Nishida H, Daa T, Yamaoka Y, Murakami K, Kobayashi T. Dysbiosis of the Gut Microbiota on the Inflammatory Background due to Lack of Suppressor of Cytokine Signalling-1 in Mice. Inflamm Intest Dis 3(3) 145-154 (2018).
  28. Kamiyama N, Soma R, Hidano S, Watanabe K, Umekita H, Fukuda C, Noguchi K, Gendo Y, Ozaki T, Sonoda A, Sachi N, Runtuwene LR, Miura Y, Matsubara E, Tajima S, Takasaki T, Eshita Y, Kobayashi T. Ribavirin inhibits Zika virus (ZIKV) replication in vitro and suppresses viremia in ZIKV-infected STAT1-deficient mice. Antiviral Res. 146 1-11 (2017).
  29. Hidano S, Randall L M, Dawson L, Dietrich H K, Konradt C, Klover P J, John B, Harris T H, Fang Q, Turek B, Kobayashi T, Hennighausen L, Beiting D P, Koshy A A, Hunter C A. STAT1 signaling in astrocytes is essential for control of infection in the central nervous system. mBio 7 (6), e01881-16, 1-15, (2016).
  30. Izumi K, Mine K, Teshima M, Kobayashi T, Yoshikai Y, Minagawa H, Kurisaki H, Akashi K, Katsuta H, Nagafuchi, et al. Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes. Nat Commun 6:e6748, (2015).
  31. Srisawat R, Phanitchat T, Komalamisra N, Tamori N, Runtuwene L, Noguchi K, Hayashida K, Hidano S, Kamiyama N, Takashima I, Takasaki T, Kurane I, Narita N, Kobayashi T, Eshita Y. Susceptibility of Aedes flavopictus miyarai and Aedes galloisi mosquito species in Japan to dengue type 2 virus. Asian Pacific Journal of Tropical Biomedicine 6 (5), 446-450, (2015).
  32. Runtuwene LR, Konishi E, Yamanaka A, Makino Y, Suzuki Y, Takasaki T, Kurane I, Kobayashi T, Eshita Y. Dengue transmission model by means of viremic adult immuno-competent mouse. Parasit Vectors 7 (1), 143, (2014).
  33. Runtuwene LR, Noguchi K, Tokunaga A, Kobayashi T, Nakai K, Eshita Y. Vector competence of Aedes aegypti to dengue virus. Urban Pest Management 4 (1), 1-14, (2014).
  34. Onish Y, Eshita Y, Ji R-C, Onishi M, Kobayashi T, Mizuno M, Yoshida J, Kubota N. Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl–dextran–MMA graft copolymer and paclitaxel used as an artificial enzyme. Beilstein J. Nanotechnol. 5, 2293–2307, (2014).
  35. Runtuwene LR, Konishi E, Yamanaka A, Makino Y, Suzuki Y, Takasaki T, Kurane I, Kobayashi T, Eshita Y. Dengue transmission model by means of viremic adult immuno-competent mouse. Parasit Vectors; 7(1):143 (2014).
  36. Inoue K, Ozaka S, Okamoto K, Ogawa R, Mizukami K, Okimoto T, Kodama M, Kobayashi T, Eshita Y, Hasegawa H, Murakami K. Multiple infections with helminths--whipworm, hookworm, and roundworm. Endoscopy; 46 Suppl 1 UCTN:E117-8. doi: 10.1055/s-0034-1364887 (2014).
  37. Muto G, Kotani H, Kondo T, Morita R, Tsuruta S, Kobayashi T, Luche H, Fehling HJ, Walsh M, Choi Y, Yoshimura A. TRAF6 Is Essential for Maintenance of Regulatory T Cells That Suppress Th2 Type Autoimmunity. PLoS One. 8(9):e74639 (2013).
  38. Matsuo T, Noguchi Y, Shindo M, Morita Y, Oda Y, Yoshida E, Hamada H, Harada M, Shiokawa Y, Nishida T, Tominaga R, Kikushige Y, Akashi K, Kudoh J, Shimizu N, Tanaka Y, Umemura T, Taniguchi T, Yoshimura A, Kobayashi T, Mitsuyama M, Kurisaki H, Katsuta H, Nagafuchi S. Regulation of human autoimmune regulator (AIRE) gene translation by miR-220b. Gene. 530(1):19-25 (2013).
  39. Eshita Y, Ji R, Onishi M, Runtuwene L, Noguchi K, Kobayashi T, Mizuno M, Yoshida J, Kubota N, Onishi Y. Supramolecular targeting of B16F10 melanoma cells with nanoparticles consisting of a DEAE-dextran-MMA copolymer-paclitaxel complex in vivo and in vitro. J. Nanomed. Biotherapeut. Discov. 2 (5), 109, (2012).
  40. Hinoi E, Ochi H, Takarada T, Nakatani E, Iezaki T, Nakajima H, Fujita H, Takahata Y, Hidano S, Kobayashi T, Takeda S, Yoneda Y. Positive regulation of osteoclastic differentiation by growth differentiation factor-15 up-regulated in osteocytic cells under hypoxia. J Bone Miner Res. 27(4): 938-949 (2012).
  41. Takaesu G, Kobayashi T, Yoshimura A. TGF{beta}-Activated Kinase 1 (TAK1)-Binding Proteins (TAB) 2 and 3 Negatively Regulate Autophagy. J Biochem. 151(2): 157-166 (2011).
  42. Mori T, Miyamoto T, Yoshida H, Asakawa M, Kawasumi M, Kobayashi T, Morioka H, Chiba K, Toyama Y, Yoshimura A. IL-1beta and TNFalpha-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis. Int Immunol. 23(11): 701-712. (2011).
  43. Miyamoto K, Yoshida S, Kawasumi M, Hashimoto K, Kimura T, Sato Y, Kobayashi T, Miyauchi Y, Hoshi H, Iwasaki R, Miyamoto H, Hao W, Morioka H, Chiba K, Kobayashi T, Yasuda H, Penninger JM, Toyama Y, Suda T and Miyamoto T. Osteoclasts are dispensable for haematopoietic stem cell maintenance and mobilization. J Exp Med. 208(11): 2175-2181 (2011).
  44. Nagamatsu G, Kosaka T, Kawasumi M, Kinoshita T, Takubo K, Akiyama H, Sudo T, Kobayashi T,  Oya M, and Suda T.: A germ cell specific gene, Prmt5 works as somatic cell reprogramming.  J Biol Chem. 286(12): 10641-10648. (2011). 【IF:5.328】
  45. Nakaya M, Hamano S, Kawasumi M, Yoshida H, Yoshimura A, Kobayashi T. Aberrant IL-4 production by SOCS3-over-expressing T cells during infection with Leishmania major exacerbates disease manifestations. Int Immunol. 23, 195-202, (2011).
  46. Hashimoto M, Ayada T, Kinjyo I, Hiwatashi K, Yoshida H, Okada Y, Kobayashi T, Yoshimura A. Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation.  Cancer Sci. 100(4):730-736. (2009). 【IF:3.846】
  47. Kobayashi T, Kim TS, Jacob A, Walsh MC, Kadono Y, Fuentes-Pananá E, Yoshioka T, Yoshimura A, Yamamoto M, Kaisho T, Akira S, Monroe JG, Choi Y. TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses. PLoS ONE.;4(3):e4736. (2009). 【IF:4.411】
  48. Saeki K, Fukuyama S, Ayada T, Nakaya M, Aki D, Takaesu G, Hanada T, Matsumura Y, Kobayashi T, Nakagawa R, Yoshimura A. A major lipid raft protein raftlin modulates T cell receptor signaling and enhances th17-mediated autoimmune responses. J Immunol. 182(10): 5929-5937. (2009). 【IF:5.745】
  49. Minoda Y, Sakurai H, Kobayashi T, Yoshimura A, Takaesu G. An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway. Biochem Biophys Res Commun. 381(3): 412-417. (2009). 【IF:2.595】
  50. Yoshimura T, Sonoda KH, Ohguro N, Ohsugi Y, Ishibashi T, Cua DJ, Kobayashi T, Yoshida H, Yoshimura A. Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis. Rheumatology (Oxford). 48(4):347-354. (2009). 【IF:4.171】
  51. Koga K, Takaesu G, Yoshida R, Nakaya M, Kobayashi T, Kinjyo I, Yoshimura A. Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein. Immunity 30(3): 372-383 (2009). 【IF:24.221】
  52. Nakashima D, *Kabashima K, Sakabe J, Sugita K, Kobayashi T, Yoshiki R, Tokura Y. Impaired initiation of contact hypersensitivity by FTY720. J Invest Dermatol. 128(12): 2833-2841. (2008). 【IF:6.270】
  53. Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, *Kobayashi T. TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like Helicase Antiviral Pathway. J Biol Chem. 283(52): 36211-36220. (2008). 【IF:5.328】
  54. Sanada T, Takaesu G, Mashima R, Yoshida R, Kobayashi T, Yoshimura A. FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway. J Biol Chem. 283(49): 33858-33864. (2008). 【IF:5.328】
  55. Shiraishi H, Yoshida H, Saeki K, Miura Y, Watanabe S, Ishizaki T, Hashimoto M, Takaesu G, Kobayashi T, Yoshimura A. Prostaglandin E2 is a major soluble factor produced by stromal cells for preventing inflammatory cytokine production from dendritic cells. Int Immunol. 20(9):1219-1229. (2008). 【IF:3.301】
  56. Ichiyama K, Yoshida H, Wakabayashi Y, Chinen T, Saeki K, Nakaya M, Takaesu G, Hori S, *Yoshimura A, *Kobayashi T. Foxp3 inhibits RORgamma t-mediated IL-17A mRNA transcription through direct interaction with RORgamma t. J Biol Chem. 283(25): 17003-17008. (2008). 【IF:5.328】
  57. Takaki H, Ichiyama K, Koga K, Chinen T, Takaesu G, Sugiyama Y, Kato S, *Yoshimura A, *Kobayashi T. STAT6 inhibits TGF-beta 1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor. J Biol Chem. 283(22): 14955-14962. (2008). 【IF:5.328】
  58. Torisu T, Nakaya M, Watanabe S, Hashimoto M, Yoshida H, Chinen T, Yoshida R, Okamoto F, Hanada T, Torisu K, Takaesu G, Kobayashi T, Yasukawa H, Yoshimura A. Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis. Hepatology. 47(5): 1644-1654. (2008). 【IF:10.885】
  59. Tanaka K, Ichiyama K, Hashimoto M, Yoshida H, Takimoto T, Takaesu G, Torisu T, Hanada T, Yasukawa H, Fukuyama S, Inoue H, Nakanishi Y, Kobayashi T, Yoshimura A. Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads. J Immunol. 180(6): 3746-3756. (2008). 【IF:5.745】
  60. King CG, Buckler JL, Kobayashi T, Hannah JR, Bassett G, Kim T, Pearce EL, Kim GG, Turka LA, Choi Y. Cutting edge: requirement for TRAF6 in the induction of T cell anergy. J Immunol. 180(1): 34-38 (2008). 【IF:5.745】
  61. Yu Q, Minoda Y, Yoshida R, Yoshida H, Iha H, Kobayashi T, Yoshimura A, Takaesu G. HTLV-1 Tax-mediated TAK1 activation involves TAB2 adapter protein. Biochem Biophys Res Commun. 365(1): 189-194 (2008). 【IF:2.595】
  62. Le Y, Zhu BM, Harley B, Park SY, Kobayashi T, Manis JP, Luo HR, Yoshimura A, Hennighausen L, Silberstein LE. SOCS3 Protein Developmentally Regulates the Chemokine Receptor CXCR4-FAK Signaling Pathway during B Lymphopoiesis. Immunity. 27(5): 811-823. (2007). 【IF:24.221】
  63. Yamauchi M, Hashimoto M, Ichiyama K, Yoshida R, Hanada T, Muta T, Komune S, Kobayashi T, Yoshimura A.Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-{kappa}B activation in dendritic cells. Int Immunol. 19(8): 935-942. (2007). 【IF:3.301】
  64. Matsumura Y, Kobayashi T, Ichiyama K, Yoshida R, Hashimoto M, Takimoto T, Tanaka K, Chinen T, Shichita T, Wyss-Coray T, Sato K, *Yoshimura A. Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells. J Immunol. 179(4): 2170-2179. (2007). 【IF:5.745】
  65. Mori H, Shichita T, Yu Q, Yoshida R, Hashimoto M, Okamoto F, Torisu T, Nakaya M, Kobayashi T, Takaesu G, Yoshimura A. Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes. Biochem Biophys Res Commun. 359(4): 952-958. (2007).
  66. Nishinakamura H, Minoda Y, Saeki K, Koga K, Takaesu G, Onodera M, Yoshimura A, *Kobayashi T. An RNA-binding protein alpha CP-1 is involved in the STAT3-mediated suppression of NF-kappaB transcriptional activity. Int Immunol. 19(5): 609-619. (2007). 【IF:3.301】
  67. Hamazaki Y, Fujita H, Kobayashi T, Choi Y, Scott HS, Matsumoto M, Minato N. Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. Nat Immunol. 8(3): 304-311. (2007). 【IF:25.668】
  68. Yoshiga D, Sato N, Torisu T, Mori H, Yoshida R, Nakamura S, Takaesu G, Kobayashi T, Yoshimura A. Adaptor protein SH2-B linking receptor-tyrosine kinase and Akt promotes adipocyte differentiation by regulating peroxisome proliferator-activated receptor gamma messenger ribonucleic acid levels. Mol Endocrinol. 21(5): 1120-1131. (2007). 【IF:4.889】
  69. Torisu T, Sato N, Yoshiga D, Kobayashi T, Yoshioka T, Mori H, Iida M, Yoshimura A. The dual function of hepatic SOCS3 in insulin resistance in vivo. Genes Cells. 12(2): 143-154. (2007). 【IF:2.889】
  70. Lu Y, Fukuyama S, Yoshida R, Kobayashi T, Saeki K, Shiraishi H, Yoshimura A, Takaesu G. Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic. J Biol Chem. 281(48): 36683-36690 (2006). 【IF:5.328】
  71. King CG, Kobayashi T, Cejas PJ, Kim T, Yoon K, Kim GK, Chiffoleau E, Hickman SP, Walsh PT, Turka LA, *Choi Y. TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat Med. 12(9):1088-1092. (2006). 【IF:25.430】
  72. Takaki H, Minoda Y, Koga K, Takaesu G, Yoshimura A, Kobayashi T. TGF-beta1 suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation. Genes Cells. 11(8):871-882. (2006). 【IF:2.889】
  73. Ogata H, Kobayashi T, Chinen T, Takaki H, Sanada T, Minoda Y, Koga K, Takaesu G, Maehara Y, Iida M, Yoshimura A. Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis. Gastroenterology. 131(1):179-193. (2006). 【IF:12.032】
  74. #Hanada T, #Kobayashi T, Chinen T, Saeki K, Takaki H, Koga K, Minoda Y, Sanada T, Yoshioka T, Mimata H, Kato S, Yoshimura A. IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. J Exp Med. 203(6):1391-1397. (2006). #equally contributed
  75. Minoda Y, Saeki K, Aki D, Takaki H, Sanada T, Koga K, Kobayashi T, Takaesu G, Yoshimura A. A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling. Biochem Biophys Res Commun. 344(3):1023-1030. (2006). 【IF:2.595】
  76. Kinjyo I, Inoue H, Hamano S, Fukuyama S, Yoshimura T, Koga K, Takaki H, Himeno K, Takaesu G, Kobayashi T, Yoshimura A. Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1. J Exp Med. 203(4):1021-1031. (2006). 【IF:14.776】
  77. Ogata H, Chinen T, Yoshida T, Kinjyo I, Takaesu G, Shiraishi H, Iida M, Kobayashi T, Yoshimura A. Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production. Oncogene. 25(17):2520-2530. (2006). 【IF:7.414】
  78. Chinen T, Kobayashi T, Ogata H, Takaesu G, Takaki H, Hashimoto M, Yagita H, Nawata H, Yoshimura A. Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved. Gastroenterology. 130(2):373-388. (2006). 【IF:12.032】
  79. Mashima R, Saeki K, Aki D, Minoda Y, Takaki H, Sanada T, Kobayashi T, Aburatani H, Yamanashi Y, Yoshimura A. FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling. J Biol Chem. 280(50):41289-41297. (2005). 【IF:5.328】
  80. Taketomi T, Yoshiga D, Taniguchi K, Kobayashi T, Nonami A, Kato R, Sasaki M, Sasaki A, Ishibashi H, Moriyama M, Nakamura K, Nishimura J, Yoshimura. A Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia. Nat Neurosci. 8(7):855-857. (2005). 【IF:14.191】
  81. Kim N, Kadono Y, Takami M, Lee J, Lee SH, Okada F, Kim JH, Kobayashi T, Odgren PR, Nakano H, Yeh WC, Lee SK, Lorenzo JA, Choi Y. Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis. J Exp Med. 202(5):589-595. (2005). 【IF:14.776】
  82. Hanada T, Tanaka K, Matsumura Y, Yamauchi M, Nishinakamura H, Aburatani H, Mashima R, Kubo M, Kobayashi T, Yoshimura A. Induction of hyper Th1 cell-type immune responses by dendritic cells lacking the suppressor of cytokine signaling-1 gene. J Immunol. 174(7):4325-4332. (2005). 【IF:5.745】
  83. Ohishi M, Matsumura Y, Aki D, Mashima R, Taniguchi K, Kobayashi T, Kukita T, Iwamoto Y, Yoshimura A. Suppressors of cytokine signaling-1 and -3 regulate osteoclastogenesis in the presence of inflammatory cytokines. J Immunol. 174(5):3024-3031. (2005). 【IF:5.745】
  84. #Mason NJ, #Fiore J, #Kobayashi T, Masek KS, Choi Y, Hunter CA. TRAF6-dependent mitogen-activated protein kinase activation differentially regulates the production of interleukin-12 by macrophages in response to Toxoplasma gondii. Infect Immun. 72(10):5662-5667 (2004). (#: shared first authors) 【IF:4.098】 #equally contributed
  85. Chiffoleau E, Kobayashi T, Walsh MC, King CG, Walsh PT, Hancock WW, Choi Y, Turka LA. TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-polarized inflammatory disease. J. Immunol. 171(11) 5751-5759 (2003). 【IF:5.745】
  86. Kobayashi T, Walsh PT, Walsh MC, Speirs KM, Chiffoleau E, King CG, Hancock WW, Caamano JH, Hunter CA, Scott P, Turka LA, Choi Y. TRAF6 is a critical factor for dendritic cell maturation and development. Immunity 19(3), 353-363. (2003). 【IF:24.221】
  87. Ogawa T, Maeda K, Tonai S, Kobayashi T, Watanabe T, Okabe S. Utilization of knockout mice to examine the potential role of gastric histamine H2-receptors in Menetrier's disease. J. Pharmacol. Sci. 91(1):61-70 (2003). 【IF:2.260】
  88. Hayashi K, Kobayashi T, Umino T, Goitsuka R, Matsui Y, Kitamura D. SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast. Mech Dev. Oct;118(1-2):99-109. (2002). 【IF:2.958】
  89. Arron JR, Pewzner-Jung Y, Walsh MC, Kobayashi T, Choi Y. Regulation of the Subcellular Localization of Tumor Necrosis Factor Receptor associated Factor (TRAF)2 by TRAF1 Reveals Mechanisms of TRAF2 Signaling J. Exp. Med. 196(7), 923-934. (2002). 【IF:14.776】
  90. Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, Segal D, Dzivenu OK, Vologodskaia M, Yim M, Du MK, Singh S, Pike JW, Darnay BG, Choi Y, Wu H. Distinct molecular mechanism for initiating TRAF6 signalling. Nature. 418(6896): 443-447. (2002). 【IF:36.101】
  91. Jutel M, Watanabe T, Klunker S, Akdis M, Thomet OA, Malolepszy J, Zak-Nejmark T, Koga R, Kobayashi T, Blaser K, Akdis CA. Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors. Nature. 413(6854): 420-425. (2001). 【IF:36.101】
  92. Kobayashi T, Tonai S, Ishihara Y, Koga R, Okabe S, Watanabe T. Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor-deficient mice. J. Clin. Inves. 105(12):1741-1749 (2000). 【IF:14.152】
  93. Marguet D, Baggio L, Kobayashi T, Bernard AM, Pierres M, Nielsen PF, Ribel U, Watanabe T, Drucker DJ, Wagtmann N. Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26. Proc. Natl Acad Sci. USA. 97(12):6874-6879 (2000). 【IF:9.771】
  94. Sato M, Kawarabayashi T, Shoji M, Kobayashi T, Tada N, Matsubara E, Hirai S. Neurodegeneration and gliosis in transgenic mice overexpressing a carboxy-terminal fragment of Alzheimer amyloid-beta protein procursor. Dement Geriatr Cogn Disord 8, 296-307 (1997). 【IF:2.455】
  95. Sato M, Kawarabayashi T, Shoji M, Kobayashi T, Hirai S, Tada N. Cytomegalovirus enhancer/chicken b-actin promotor confers constitutive and ubiquitous transgene expression in vivo. Transgenics 2, 153-159 (1997). 【IF:0.773】
  96. Noguchi M, Watanabe C, Kobayashi T, Kuwashima M, Sakurai T, Katoh H, Moriwaki K. The ter mutation responsible for germ cell deficincy but not testicular not ovarian teratocaarcinogenesis in ter/ter congenic mice. Develop. Growth Differ. 38, 59-69 (1996). 【IF:2.284】
  97. Kawarabayashi T, Shoji M, Sato M, Sasaki A, Ho L, Eckman CB, Prada CM, Younkin SG, Kobayashi T, Tada N, Matsubara E, Iizuka T, Harigaya Y, Kasai K, Hirai S. Accumulation of beta-amyloid fibrils in pancreas of transgenic mice. Neurobiology of Aging. 17 (2), 215-222 (1996). 【IF:6.634】
  98. Iizuka T, Shoji M, Kawarabayashi T, Sato M, Kobayashi T, Tada N, Kasai K, Matsubara E, Watanabe M, Tomidokoro Y, Hirai S. Intracellular generation of amyloid beta-protein from amyloid beta-protein precursor fragment by direct cleavage with beta- and gamma-secretase. Biochem Biophys Res Commun. 218(1), 238-242 (1996). 【IF:2.595】
  99. Inoue I, Yanai K, Kitamura D, Taniuchi I, Kobayashi T, Niimura K, Watanabe T, Watanabe T. Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors. Proc. Natl. Acad. Sci. USA. 93, 13316-13320 (1996). 【IF:9.771】
  100. Kobayashi T, Inoue I, Jenkins NA, Gilbert DJ, Copeland NG, Watanabe T. Cloning, RNA expression, and chromosomal location of a mouse histamine H2 receptor gene. GENOMICS 37, 390-394 (1996). 【IF:3.327】
  101. Tada N, Ikeda T, Sato M, Kitamura K, Kobayashi T, Kasai K, Hirokawa K. Genetic ablation of osteoblasts causes osteopenia without affecting osteoclastogenesis in transgenic mice Transgenics 1, 649-662 (1995). 【IF:0.773】

Review Papers, Case Reports and Others

  1. Ozaka S, Kobayashi T, Mizukami K, Murakami K. COVID-19 vaccination and liver disease. World J Gastroenterol. (2022). Dec 28;28(48):6791-6810. doi: 10.3748/wjg.v28.i48.6791. PMID: 36632314.
  2. Ozaka S, Kodera T, Tsutsumi K, Fukuda M, Iwao M, Hirashita Y, Takahashi H, Fukuda K, Okamoto K, Arakawa M, Ogawa R, Endo M, Mizukami K, Okimoto T, Kamiyama N, Kodama M, Kobayashi T, Murakami K. Acute Cholecystitis Associated with Eosinophilic Granulomatosis with Polyangiitis that Responded to Glucocorticoid Therapy. Intern Med. (2022). Sep 28. doi: 10.2169/internalmedicine.0437-22. Online ahead of print. PMID: 36171126.
  3. 小坂聡太郎, 小林隆志. 「第1部 日本人と食のチカラ 第2章 日本人の身体に合った食事〜腸内環境から考える日本人の理想の食〜」 （中村丁次編　『国民の栄養白書2021年度版』　日本医療企画、2022年、pp22-30). 　
  4. Ozaka S., Kodera T., Ariki S., Kobayashi T., Murakami K. Acute pancreatitis soon after COVID-19 vaccination: A case report. Medicine (Baltimore) (2022). Jan 14;101(2):e28471. doi: 10.1097/MD.0000000000028471.
  5. Ozaka S., Kobayashi T., Murakami K. Comment on “A case of acute necrotising pancreatitis following the second dose of Pfizer-BioNTech COVID-19 mRNA vaccine”. Br J Clin Pharmacol. 88(5):2449. (2022). doi:10.1111/bcp.15159
  6. Astri Dewayani , Kartika Afrida Fauzia, Ricky Indra Alfaray, Langgeng Agung Waskito , Dalla Doohan, Yudith Annisa Ayu Rezkitha, Abdurachman Abdurachman, Takashi Kobayashi, Reny I’tishom, Yoshio Yamaoka, Muhammad Miftahussurur. The Roles of IL-17, IL-21, and IL-23 in the Helicobacter pylori Infection and gastrointestinal Inflammation: A Review. Toxins. Apr 28;13(5):315. (2021). doi: 10.3390/toxins13050315.
  7. 石部 智也, 日野 翔太, 岸 大地, 横山 勝彦, 瀬戸 陽子, 飛彈野 真也, 小林隆志, 長谷川 英男, 久保田 敏昭. 遺伝子解析を行った結膜寄生の東洋眼虫症の2例 . 臨床眼科 75(8). 1026-1030. (2021). https://doi.org/10.11477/mf.1410214063
  8. 神山長慶、佐知望美、飛彈野真也、小林隆志. 蚊媒介性ウイルス疾患. 臨床免疫・アレルギー科 68 (1), 79-85. (2017).
  9. 飛彈野真也、水上一弘、佐知望美、神山長慶、小林隆志. アニサキス症の最近の知見と動向. 医学と薬学 74巻 11号 1387 -1392. (2017).
  10. 江下優樹、Runtuwene　Ronald　Lucky、林田京子、飛彈野真也、神山長慶、小林隆志. 迫り来る蚊媒介性感染症。特集「新興・再興感染症と感染症対策」. 生体の科学 66 (4), 352-355. (2015).
  11. 小林隆志、飛彈野真也. サイトカインシグナル抑制因子SOCSによるIgE産生の制御. 臨床免疫・アレルギー科 56(2): 151-158. (2011).
  12. 永淵正法，塚本 浩，新納宏昭，小林隆志. 自己免疫疾患と炎症. 医学のあゆみ 226(4): 265-271. (2008).
  13. 小林隆志、川澄みゆり、濱野真二郎. 感染症制御における制御性T細胞. アレルギー・免疫 16 (5): 708-714. (2009).
  14. 知念孝敏、金城市子、吉村昭彦、小林隆志. TGF-β, IL-10を産生する抑制性ヘルパーT細胞の誘導とSTAT3/SOCS3による制御. 臨床免疫・アレルギー科 50(2): 238-246. (2008).
  15. 吉村昭彦、小林隆志. SOCSによるTh17分化の制御. 医学のあゆみ 226(4): 265-271. (2008).
  16. 吉村昭彦、知念孝敏、市山健司、小林隆志. サイトカインによるTh17とiTregの分化制御. 細胞工学　27(2): 137-143. (2008).
  17. 吉村昭彦、田中謙太郎、岡元冬樹、小林隆志. 細胞内制御シグナルとアレルギー疾患. アレルギー　56 (6): 563-569. (2007).
  18. 田中謙太郎、市山健司、橋本雅之、小林隆志、吉村昭彦. SOCS1/SOCS3によるTh細胞の分化制御. 臨床免疫・アレルギー科　48(4): 354-361. (2007).
  19. 金城市子、田中謙太郎、吉村昭彦、小林隆志. SOCS3 STAT3によるTh3 Th17の制御. 臨床免疫・アレルギー科　47(1): 33-39. (2007).
  20. 吉村昭彦，小林隆志，知念孝敏. SOCS遺伝子による炎症とT細胞分化の制御. Medical Science Digest 32(12), 20(534)-23(537). (2006).
  21. 吉村昭彦，高木宏美，古賀敬子，小林隆志. 自己免疫疾患とシグナル伝達制御. 遺伝子医学 6, 198-205. (2006).
  22. Kobayashi T, Takaesu G, Yoshimura A. Mal-function of TLRs by SOCS. Nat Immunol. 7(2):123-124. (2006).
  23. 吉村　明彦、花田　俊勝、小林　隆志、盛　裕之、真嶋　隆一. SOCS遺伝子によるサイトカインシグナルの制御. 実験医学（増刊）シグナル伝達研究2005-06: 23(11) 1727-1734. (2005).
  24. 吉村　明彦、小林　隆志、真田　貴人、高江洲　義一 . SOCS遺伝子による免疫制御. 臨床免疫 44(2) 169-178. (2005).
  25. 吉村　明彦、白石　裕士、高木　宏美、小林　隆志 . 自己免疫疾患とシグナル伝達. 実験医学　23(3) 377-384. (2005).
  26. Kobayashi T, Yoshimura A. Keeping DCs awake by putting SOCS1 to sleep. Trends Immunol. 26(4):177-179. (2005).
  27. Kobayashi T, Walsh MC, Choi Y. The role of TRAF6 in signal transduction and the immune response. Microbes Infect. 6(14) 1333-1338. (2004).
  28. 小林　隆志, サイトカン／TLRとTRAF6. Molecular Medicine 40(11), 1280-1287 (2003).

招待講演

  1. 2021年8月20日　　 International Meeting_the 3rd Chulalongkorn-Oita University Joint Mini-Symposium
    　　　　　　　　　 「Immune regulation in Toxoplasma infection」 (online, Thailand)
  2. 2021年6月9日　　Seminar at International Meeting_the 5th MSU International Veterinary Conference：
    　　　　　　　　　 「Host immune response to Toxoplasma gondii infection」 (online, Thailand)
  3. 2020年2月20日　　Chulalongkorn大学医学部・理学部微生物学講座合同セミナー：
    　　　　　　　　　 「ZIKA virus infection and immune response in mouse model」 (Bangkok, Thailand)
  4. 2020年月19日　　　Mahidol大学理学部病態生物学部門セミナー：
    　　　　　　　　　 「ZIKA virus control and immune response in mouse model」 (Bangkok, Thailand)
  5. 2018年8月5日　　　免疫ふしぎ未来：「身近な寄生虫について」 （お台場、東京）
  6. 2018年8月3日　　　理化学研究所IMSセミナー：「アニサキスについて」 （横浜市）
  7. 2017年4月17日　　　大分郡市医師会学術講演会：「抗体医薬品を支える科学技術」 （大分市）
  8. 2016年12月20日　　　大分大学学術セミナー：「疾患モデルマウスを用いた炎症病態の研究」 （由布市）
  9. 2016年7月30日　　　埼玉リウマチ・膠原病フォーラム：「自己免疫疾患について」 （さいたま市）
  10. 2012年11月10日　　　第3回癌・炎症と抗酸化研究会：「炎症発癌」 （由布市）
  11. 2012年5月25日　　　大分大学遺伝子改変マウス研究推進セミナー：「遺伝子改変マウスの研究動向について」 （由布市）
  12. 2011年2月26日　　　第7回宮崎サイエンスキャンプ：「SOCS1による病態制御」 （宮崎市）
  13. 2010年7月7日　　　千葉大学G-COEセミナー：「SOCS1によるリンパ球の活性化制御」 （千葉市）
  14. 2009年6月26日　　　第７４回日本インターフェロン・サイトカイン学会学術集会：「TRAF6によるウイルス感染防御」 （京都市）
  15. 2007年11月20日　　　第37回日本免疫学会国際シンポジウム：「制御性T細胞」 （高輪、東京）
  16. 2006年6月24日　　　北海道大学　第1回ファーマサイエンスフォーラム：「SOCS1による炎症発癌」 （札幌市）
  17. 2003年5月2日　　　九州大学生医研セミナー：「TRAF6による樹状細胞の制御」 （福岡市）