論文

• 西田欣広、花田克浩．DNA二重鎖切断と婦人科関連の問題．BIO Clinica. 2023 Aug; 38(9): 54-58.
• Tomo T, Matsuyama K, Michikoshi J, Hanada K. Investigation of the inhibition of bacteria and endotoxin influx by back filtration through dialyzer membranes. J Artif Organs. 2023 Feb 10. doi: 10.1007/s10047-023-01385-0.
• Nishida M, Terabayashi T, Matsuoka S, Okuma T, Adachi S, Tomo T, Kawano M, Tanaka K, Tsumura H, Anai H, Ishizaki T, Nishida Y, Hanada K. Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition. Commun Biol. 2022 Sep 16; 5(1): 982. doi: 10.1038/s42003-022-03920-w.
• 花田克浩. 薬剤開発研究の新規手法としての循環式三次元組織培養システム. 化学工業. 2021 May; 72(5): 293-299.
• Inoue N, Terabayashi T, Takiguchi-Kawashima Y, Fujinami D, Matsuoka S, Kawano M, Tanaka K, Tsumura H, Ishizaki T, Narahara H, Kohda D, Nishida Y, Hanada K. The benzylisoquinoline alkaloids, berberine and coptisine, act against camptothecin-resistant topoisomerase I mutants. Sci Rep. 2021 Apr 8; 11(1): 7718. doi: 10.1038/s41598-021-87344-2.
• Abe I, Terabayashi T, Hanada K, Kondo H, Teshima Y, Ishii Y, Miyoshi M, Kira S, Saito S, Tsuchimochi H, Shirai M, Yufu K, Arakane M, Daa T, Thumkeo D, Narumiya S, Takahashi N, Ishizaki T. Disruption of Actin Dynamics Regulated by Rho Effector mDia1 Attenuates Pressure Overload-Induced Cardiac Hypertrophic Responses and Exacerbates Dysfunction. Cardiovasc Res. 2021 Mar 21; 117(4): 1103-1117. doi: 10.1093/cvr/cvaa206.
• Oka Y, Hamada M, Nakazawa Y, Muramatsu H, Okuno Y, Higasa K, Shimada M, Takeshima H, Hanada K, Hirano T, Kawakita T, Sakaguchi H, Ichimura T, Ozono S, Yuge K, Watanabe Y, Kotani Y, Yamane M, Kasugai Y, Tanaka M, Suganami T, Nakada S, Mitsutake N, Hara Y, Kato K, Mizuno S, Miyake N, Kawai Y, Tokunaga K, Nagasaki M, Kito S, Isoyama K, Onodera M, Kaneko H, Matsumoto N, Matsuda F, Matsuo K, Takahashi Y, Mashimo T, Kojima S, Ogi T. Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome. Sci Adv. 2020 Dec 18; 6(51): eabd7197. doi: 10.1126/sciadv.abd7197.
• 花田克浩. 再生医学研究を変える新技術としての循環式三次元組織培養システム. クリーンテクノロジー. 2020 Feb; 30(2): 46-50. Sannomiya R, Ichiki R, Otani R, Hanada K, Sonoda M, Akamine S, Kanazawa S. Investigation on Hard-Tissue Compatibility of TiN Surface Formed by Atmospheric-Pressure-Plasma Nitriding. Plasma and Fusion Research: Letters, 2018 Dec 11; 13: 1306120. doi.org/10.1585/pfr.13.1306120.
• Terabayashi T, Hanada K. Genome instability syndromes caused by impaired DNA repair and aberrant DNA damage responses. Cell Biol Toxicol. 2018 Oct; 34(5): 337-350. doi: 10.1007/s10565-018-9429-x.
• Maki R, Matsukawa M, Matsuduka A, Hashinaga M, Anai H, Yamaoka Y, Hanada K (Corresponding author), Fujii C. Therapeutic effect of lyophilized, Kefir-fermented milk on constipation among persons with mental and physical disabilities. Jpn J Nurs Sci. 2018 Jul; 15(3): 218-225. doi: 10.1111/jjns.12189.
• Terabayashi T, Hanada K, Motani K, Kosako H, Yamaoka M, Kimura T, Ishizaki T. Baicalein disturbs the morphological plasticity and motility of breast adenocarcinoma cells depending on the tumor microenvironment. Genes Cells. 2018 Jun; 23(6): 466-479. doi: 10.1111/gtc.12584.
• Teshima R, Hanada K, Akada J, Kawano K, Yamaoka Y. Aggregatibacter actinomycetemcomitans infection causes DNA double-strand breaks in host cells. Genes Cells. 2018 Apr; 23(4): 264-273. doi: 10.1111/gtc.12570.
• Kawashima Y, Yamaguchi N, Teshima R, Narahara H, Yamaoka Y, Anai H, Nishida Y, Hanada K. Detection of DNA double-strand breaks by pulsed-field gel electrophoresis. Genes Cells. 2017 Jan; 22(1): 84-93. Erratum in: Genes Cells. 2017 Jun; 22(6): 602. PMID: 27976495.doi: 10.1111/gtc.12457.
• 花田克浩. 2重鎖切断修復機構としての相同組換え. 生物工学会誌. 2016 Jul; 94: 420-424.
• Hashimoto S, Anai H, Hanada K. Mechanisms of interstrand DNA crosslink repair and human disorders. Genes Environ. 2016 May 1; 38: 9. doi: 10.1186/s41021-016-0037-9.
• Tokunaga A, Anai H, Hanada K. Mechanisms of gene targeting in higher eukaryotes. Cell Mol Life Sci. 2016 Feb; 73(3): 523-533. doi: 10.1007/s00018-015-2073-1.
• Hirose-Matsuda H, Okamoto O, Sakai T, Ito A, Kai Y, Hatano Y, Hanada K, Yamaoka Y, Fujiwara S. Multiple malignant changes and recurrent infections in the skin associated with long-term exposure to ultraviolet light and topical psoralen plus ultraviolet A therapy. J Dermatol. 2015 May; 42(5): 536-537. doi: 10.1111/1346-8138.12835.
• Chu WK, Payne MJ, Beli P, Hanada K, Choudhary C, Hickson ID. FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51. Nat Commun. 2015 Jan 14; 6: 5931. doi: 10.1038/ncomms6931.
• Hanada K, Uchida T, Tsukamoto Y, Watada M, Yamaguchi N, Yamamoto K, Shiota S, Moriyama M, Graham DY, Yamaoka Y. Helicobacter pylori infection introduces DNA double-strand breaks in host cells. Infect Immun. 2014 Oct; 82(10): 4182-4189. doi: 10.1128/IAI.02368-14.
• Hanada K, Yamaoka Y. Genetic battle between Helicobacter pylori and humans. The mechanism underlying homologous recombination in bacteria, which can infect human cells. Microbes Infect. 2014 Oct; 16(10): 833-839. doi: 10.1016/j.micinf.2014.08.001.
• Hanada K, Graham DY. Helicobacter pylori and the molecular pathogenesis of intestinal-type gastric carcinoma. Expert Rev Anticancer Ther. 2014 Aug; 14(8): 947-954. doi: 10.1586/14737140.2014.911092.
• Simandlova J, Zagelbaum J, Payne MJ, Chu WK, Shevelev I, Hanada K, Chatterjee S, Reid DA, Liu Y, Janscak P, Rothenberg E, Hickson ID. FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells. J Biol Chem. 2013 Nov 22; 288(47): 34168-34180. doi: 10.1074/jbc.M113.484493.
• Fugger K, Chu WK, Haahr P, Kousholt AN, Beck H, Payne MJ, Hanada K, Hickson ID, Sørensen CS. FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress. Nat Commun. 2013; 4: 1423. doi: 10.1038/ncomms2395.
• Eppink B, Tafel AA, Hanada K, van Drunen E, Hickson ID, Essers J, Kanaar R. The response of mammalian cells to UV-light reveals Rad54-dependent and independent pathways of homologous recombination. DNA Repair (Amst). 2011 Nov 10; 10(11): 1095-1105. doi: 10.1016/j.dnarep.2011.08.006.
• Shiota S, Murakami K, Yoshiiwa A, Yamamoto K, Ohno S, Kuroda A, Mizukami K, Hanada K, Okimoto T, Kodama M, Abe K, Yamaoka Y, Fujioka T. The relationship between Helicobacter pylori infection and Alzheimer's disease in Japan. J Neurol. 2011 Aug; 258(8): 1460-1463. doi: 10.1007/s00415-011-5957-5.
• Vrouwe MG, Pines A, Overmeer RM, Hanada K, Mullenders LH. UV-induced photolesions elicit ATR-kinase-dependent signaling in non-cycling cells through nucleotide excision repair-dependent and -independent pathways. J Cell Sci. 2011 Feb 1; 124(Pt 3): 435-446. doi: 10.1242/jcs.075325.
• Abdel-Rahman MA, Tashiro Y, Zendo T, Hanada K, Shibata K, Sonomoto K. Efficient homofermentative L-(+)-lactic acid production from xylose by a novel lactic acid bacterium, Enterococcus mundtii QU 25. Appl Environ Microbiol. 2011 Mar; 77(5): 1892-1895. doi: 10.1128/AEM.02076-10.
• Shiota S, Matsunari O, Watada M, Hanada K, Yamaoka Y. Systematic review and meta-analysis: the relationship between the Helicobacter pylori dupA gene and clinical outcomes. Gut Pathog. 2010 Oct 31; 2(1): 13. doi: 10.1186/1757-4749-2-13.
• Chu WK, Hanada K, Kanaar R, Hickson ID. BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells. Oncogene. 2010 Aug 19; 29(33): 4705-4714. doi: 10.1038/onc.2010.214.
• Oshiro M, Hanada K, Tashiro Y, Sonomoto K. Efficient conversion of lactic acid to butanol with pH-stat continuous lactic acid and glucose feeding method by Clostridium saccharoperbutylacetonicum. Appl Microbiol Biotechnol. 2010 Jul; 87(3): 1177-1185. doi: 10.1007/s00253-010-2673-5.
• Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ. XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair. Mol Cell Biol. 2009 Dec; 29(24): 6427-6437. doi: 10.1128/MCB.00086-09.
• Hanada K, Budzowska M, Davies SL, van Drunen E, Onizawa H, Beverloo HB, Maas A, Essers J, Hickson ID, Kanaar R. The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks. Nat Struct Mol Biol. 2007 Nov; 14(11): 1096-1104. doi: 10.1038/nsmb1313.
• Shiraishi K, Ogata Y, Hanada K, Kano Y, Ikeda H. Roles of the DNA binding proteins H-NS and StpA in homologous recombination and repair of bleomycin-induced damage in Escherichia coli. Genes Genet Syst. 2007 Oct; 82(5): 433-439. doi: 10.1266/ggs.82.433.
• Hanada K, Hickson ID. Molecular genetics of RecQ helicase disorders. Cell Mol Life Sci. 2007 Sep; 64(17): 2306-2322. doi: 10.1007/s00018-007-7121-z.
• Hanada K, Vermeij M, Garinis GA, de Waard MC, Kunen MG, Myers L, Maas A, Duncker DJ, Meijers C, Dietz HC, Kanaar R, Essers J. Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice. Circ Res. 2007 Mar 16; 100(5): 738-746. doi: 10.1161/01.RES.0000260181.19449.95.
• Hanada K, Budzowska M, Modesti M, Maas A, Wyman C, Essers J, Kanaar R. The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks. EMBO J. 2006 Oct 18; 25(20): 4921-432. doi: 10.1038/sj.emboj.7601344.
• Garinis GA, Mitchell JR, Moorhouse MJ, Hanada K, de Waard H, Vandeputte D, Jans J, Brand K, Smid M, van der Spek PJ, Hoeijmakers JH, Kanaar R, van der Horst GT. Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks. EMBO J. 2005 Nov 16; 24(22): 3952-3962. doi: 10.1038/sj.emboj.7600849.
• Budzowska M, Jaspers I, Essers J, de Waard H, van Drunen E, Hanada K, Beverloo B, Hendriks RW, de Klein A, Kanaar R, Hoeijmakers JH, Maas A. Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination. EMBO J. 2004 Sep 1; 23(17): 3548-3558. doi: 10.1038/sj.emboj.7600353.
• McPherson JP, Lemmers B, Chahwan R, Pamidi A, Migon E, Matysiak-Zablocki E, Moynahan ME, Essers J, Hanada K, Poonepalli A, Sanchez-Sweatman O, Khokha R, Kanaar R, Jasin M, Hande MP, Hakem R. Involvement of mammalian Mus81 in genome integrity and tumor suppression. Science. 2004 Jun 18; 304(5678): 1822-1826. doi: 10.1126/science.1094557.
• Abraham J, Lemmers B, Hande MP, Moynahan ME, Chahwan C, Ciccia A, Essers J, Hanada K, Chahwan R, Khaw AK, McPherson P, Shehabeldin A, Laister R, Arrowsmith C, Kanaar R, West SC, Jasin M, Hakem R. Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J. 2003 Nov 17; 22(22): 6137-6147. doi: 10.1093/emboj/cdg580.
• Shiraishi K, Hanada K, Iwakura Y, Ikeda H. Roles of RecJ, RecO, and RecR in RecET-mediated illegitimate recombination in Escherichia coli. J Bacteriol. 2002 Sep; 184(17): 4715-4721. doi: 10.1128/jb.184.17.4715-4721.2002.
• Hanada K, Yamashita T, Shobuike Y, Ikeda H. Role of DnaB helicase in UV-induced illegitimate recombination in Escherichia coli. J Bacteriol. 2001 Sep; 183(17): 4964-4969. doi: 10.1128/jb.183.17.4964-4969.2001.
• 花田克浩、池田日出男. DNAの切断再結合による非相同組換え．蛋白質核酸酵素. 2001 Jun;46(8 Suppl): 1063-1072.
• Onda M, Yamaguchi J, Hanada K, Asami Y, Ikeda H. Role of DNA ligase in the illegitimate recombination that generates bio-transducing phages in Escherichia coli. Genetics. 2001 May; 158(1): 29-39.
• Shanado Y, Hanada K, Ikeda H. Suppression of -ray-induced illegitimate recombination in Escherichia coli by the DNA-binding protein H-NS. Mol Genet Genomics. 2001 Apr; 265(2): 242-248. doi: 10.1007/s004380000399.
• Hanada K, Iwasaki M, Ihashi S, Ikeda H. UvrA and UvrB suppress illegitimate recombination: synergistic action with RecQ helicase. Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5989-5994. doi: 10.1073/pnas.100101297.
• Yamaguchi H, Hanada K, Asami Y, Kato JI, Ikeda H. Control of genetic stability in Escherichia coli: the SbcB 3'-5' exonuclease suppresses illegitimate recombination promoted by the RecE 5'-3' exonuclease. Genes Cells. 2000 Feb; 5(2): 101-109. doi: 10.1046/j.1365-2443.2000.00309.x.
• 花田克浩、池田日出男. DNA２本鎖切断とエンドジョイニング複合体．蛋白質核酸酵素. 1999 Sep;44(12 Suppl):1838-1844.
• Yamashita T, Hanada K, Iwasaki M, Yamaguchi H, Ikeda H. Illegitimate recombination induced by overproduction of DnaB helicase in Escherichia coli. J Bacteriol. 1999 Aug; 181(15): 4549-4553. doi: 10.1128/JB.181.15.4549-4553.1999.
• Onda M, Hanada K, Kawachi H, Ikeda H. Escherichia coli mutM suppresses illegitimate recombination induced by oxidative stress. Genetics. 1999 Feb; 151(2): 439-446.
• Hisatomi Y, Hanada K, Iida S. The retrotransposon RTip1 is integrated into a novel type of minisatellite, MiniSip1, in the genome of the common morning glory and carries another new type of minisatellite, MiniSip2. Theor Appl Genet. 1997 Nov; 95(7): 1049-1056. doi.org/10.1007/s001220050661
• Hanada K, Ukita T, Kohno Y, Saito K, Kato J, Ikeda H. RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli. Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8): 3860-3865. doi: 10.1073/pnas.94.8.3860.